Seroatlas · Human Serome Atlas

TCEANC

Transcription elongation factor A N-terminal and central domain-containing protein

Also known as: MGC17403, TEANC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8B7
Gene: TCEANC
Ensembl: ENSG00000176896
Chromosome: X
Canonical length: 351 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q8N8B7|TCEANC
     1  MSDKNQIAAR ASLIEQLMSK RNFEDLGNHL TELETIYVTK EHLQETDVVR AVYRVLKNCP
    61  SVALKKKAKC LLSKWKAVYK QTHSKARNSP KLFPVRGNKE ENSGPSHDPS QNETLGICSS
   121  NSLSSQDVAK LSEMIVPENR AIQLKPKEEH FGDGDPESTG KRSSELLDPT TPMRTKCIEL
   181  LYAALTSSST DQPKADLWQN FAREIEEHVF TLYSKNIKKY KTCIRSKVAN LKNPRNSHLQ
   241  QNLLSGTTSP REFAEMTVME MANKELKQLR ASYTESCIQE HYLPQVIDGT QTNKIKCRRC
   301  EKYNCKVTVI DRGTLFLPSW VRNSNPDEQM MTYVICNECG EQWYHSKWVC W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEANC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.3 nTPM
retina: 3.5 nTPM
thymus: 3.1 nTPM
lymph node: 3 nTPM
ovary: 2.9 nTPM
spleen: 2.8 nTPM

Single-cell type

myonuclei: 16 nCPM
plasma cells: 12 nCPM
retinal horizontal cells: 10 nCPM
neutrophils: 9.6 nCPM
erythrocytes: 9 nCPM
b-cells: 8.4 nCPM

Immune cell

basophil: 11 nTPM
eosinophil: 7.8 nTPM
T-reg: 6.6 nTPM
naive CD4 T-cell: 6.5 nTPM
memory B-cell: 6.4 nTPM
naive B-cell: 6.1 nTPM

Brain region

cerebellum: 5.5 nTPM
white matter: 5.4 nTPM
pons: 4.3 nTPM
spinal cord: 4.2 nTPM
basal ganglia: 4.1 nTPM
cerebral cortex: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.05
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEANC as an antibody target. Whether an autoantibody or antibody against TCEANC could matter depends on whether native TCEANC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEANC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEANC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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