Seroatlas · Human Serome Atlas

TCEA3

Transcription elongation factor A protein 3

Also known as: TCEA3_HUMAN, TFIIS.H

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75764
Gene: TCEA3
Ensembl: ENSG00000204219
Chromosome: 1
Canonical length: 348 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>O75764|TCEA3
     1  MGQEEELLRI AKKLEKMVAR KNTEGALDLL KKLHSCQMSI QLLQTTRIGV AVNGVRKHCS
    61  DKEVVSLAKV LIKNWKRLLD SPGPPKGEKG EEREKAKKKE KGLECSDWKP EAGLSPPRKK
   121  REDPKTRRDS VDSKSSASSS PKRPSVERSN SSKSKAESPK TPSSPLTPTF ASSMCLLAPC
   181  YLTGDSVRDK CVEMLSAALK ADDDYKDYGV NCDKMASEIE DHIYQELKST DMKYRNRVRS
   241  RISNLKDPRN PGLRRNVLSG AISAGLIAKM TAEEMASDEL RELRNAMTQE AIREHQMAKT
   301  GGTTTDLFQC SKCKKKNCTY NQVQTRSADE PMTTFVLCNE CGNRWKFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 446 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 446 nTPM
pancreas: 190 nTPM
tongue: 162 nTPM
liver: 133 nTPM
salivary gland: 83 nTPM
adrenal gland: 79 nTPM

Single-cell type

goblet cells: 274 nCPM
gastric progenitor cells: 179 nCPM
enteric transient amplifying cells: 169 nCPM
hepatocytes: 168 nCPM
colonocytes: 167 nCPM
granulosa cells: 157 nCPM

Immune cell

naive CD4 T-cell: 14 nTPM
memory CD4 T-cell: 8.4 nTPM
naive CD8 T-cell: 6.1 nTPM
myeloid DC: 2.9 nTPM
total PBMC: 2.3 nTPM
memory CD8 T-cell: 1.1 nTPM

Brain region

choroid plexus: 12 nTPM
medulla oblongata: 8.4 nTPM
spinal cord: 6.5 nTPM
white matter: 6.1 nTPM
cerebral cortex: 6 nTPM
midbrain: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEA3 as an antibody target. Whether an autoantibody or antibody against TCEA3 could matter depends on whether native TCEA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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