Seroatlas · Human Serome Atlas

TBCCD1

TBCC domain-containing protein 1

Also known as: FLJ10560, TBCC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVR7
Gene
TBCCD1
Ensembl
ENSG00000113838
Chromosome
3
Canonical length
557 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in several processes, including maintenance of Golgi location; maintenance of centrosome location; and regulation of cell shape. Located in spindle pole centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>Q9NVR7|TBCCD1
     1  MDQSRVLLWV KAEPFIVGAL QVPPPSKFSL HYLRKISTYV QIRATEGAYP RLYWSTWRHI
    61  ACGKLQLAKD LAWLYFEIFD SLSMKTPEER LEWSEVLSNC MSEEEVEKQR NQLSVDTLQF
   121  LLFLYIQQLN KVSLRTSLIG EEWPSPRNKS QSPDLTEKSN CHNKNWNDYS HQAFVYDHLS
   181  DLLELLLDPK QLTASFHSTH SSLVSREAVV ALSFLIEGTI SRARKIYPLH ELALWQPLHA
   241  DSGFSKISKT FSFYKLETWL RSCLTGNPFG TSACLKSGKK LAWAHQVEGT TKRAKIACNT
   301  HVAPRMHRLV VMSQVYKQTL AKSSDTLAGA HVKIHRCNES FIYLLSPLRS VTIEKCRNSI
   361  FVLGPVGTTL HLHSCDNVKV IAVCHRLSIS STTGCIFHVL TPTRPLILSG NQTVTFAPFH
   421  THYPMLEDHM ARTGLATVPN YWDNPMVVCR ENSDTRVFQL LPPCEFYVFI IPFEMEGDTT
   481  EIPGGLPSVY QKALGQREQK IQIWQKTVKE AHLTKDQRKQ FQVLVENKFY EWLINTGHRQ
   541  QLDSLVPPAA GSKQAAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBCCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • retina: 12 nTPM
  • thymus: 10 nTPM
  • liver: 8.8 nTPM
  • lymph node: 8.7 nTPM
  • tonsil: 8.6 nTPM

Single-cell type

  • epididymal principal cells: 61 nCPM
  • early primary spermatocytes: 59 nCPM
  • rod photoreceptor cells: 39 nCPM
  • müller glia: 37 nCPM
  • cone photoreceptor cells: 35 nCPM
  • enterocytes: 33 nCPM

Immune cell

  • T-reg: 18 nTPM
  • basophil: 16 nTPM
  • MAIT T-cell: 15 nTPM
  • NK-cell: 15 nTPM
  • memory CD8 T-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • white matter: 15 nTPM
  • cerebellum: 15 nTPM
  • pons: 14 nTPM
  • thalamus: 13 nTPM
  • basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBCCD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBCCD1 as an antibody target. Whether an autoantibody or antibody against TBCCD1 could matter depends on whether native TBCCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBCCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBCCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBCCD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...