TBATA

Protein identityUniProt · HPA

UniProt accession

Q96M53

Gene

TBATA

Ensembl

ENSG00000166220

Chromosome

10

Canonical length

351 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis and synaptic plasticity. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q96M53|TBATA
     1  MATDVQLADY PLMSPKAELK LEKKSGRKPR SPRDSGPQKE LVIPGIVDFE RIRRALRTPK
    61  PQTPGTYCFG RLSHHSFFSR HHPHPQHVTH IQDLTGKPVC VVRDFPAPLP ESTVFSGCQM
   121  GIPTISVPIG DPQSNRNPQL SSEAWKKELK ELASRVAFLT KEDELKKKEK EQKEEPLREQ
   181  GAKYSAETGR LIPASTRAVG RRRSHQGQQS QSSSRHEGVQ AFLLQDQELL VLELLCRILE
   241  TDLLSAIQFW LLYAPPKEKD LALGLLQTAV AQLLPQPLVS IPTEKLLSQL PEVHEPPQEK
   301  QEPPCSQSPK KTKISPFTKS EKPEYIGEAQ VLQMHSSQNT EKKTSKPRAE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBATA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

120 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TBATA.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hirschsprung disease, susceptibility to, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.43

gnomAD pLI

0

gnomAD missense Z

0.23

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• spermatogenesis

Cellular components

• ciliary basal body
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Protein TBATA-like
• SPATIAL

KeywordsUniProt

• Cytoplasm
• Developmental protein
• Differentiation
• Spermatogenesis

InteractionsUniProt · HPA

Protein binding partners of TBATA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UBA3
• KIF17