Seroatlas · Human Serome Atlas

TAS2R16

Taste receptor type 2 member 16

Also known as: T2R16, T2R16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYV7
Gene: TAS2R16
Ensembl: ENSG00000128519
Chromosome: 7
Canonical length: 291 aa
Protein class: G-protein coupled receptors, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q9NYV7|TAS2R16
     1  MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI SLGISRFCLQ
    61  WASMLNNFCS YFNLNYVLCN LTITWEFFNI LTFWLNSLLT VFYCIKVSSF THHIFLWLRW
   121  RILRLFPWIL LGSLMITCVT IIPSAIGNYI QIQLLTMEHL PRNSTVTDKL ENFHQYQFQA
   181  HTVALVIPFI LFLASTIFLM ASLTKQIQHH STGHCNPSMK ARFTALRSLA VLFIVFTSYF
   241  LTILITIIGT LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.9
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAS2R16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R16 as an antibody target. Whether an autoantibody or antibody against TAS2R16 could matter depends on whether native TAS2R16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R16 is annotated at the cell surface, where native TAS2R16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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