RTP3
Receptor-transporting protein 3
Also known as: LTM1, RTP3_HUMAN, TMEM7, Z3CXXC3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BQQ7
- Gene
- RTP3
- Ensembl
- ENSG00000163825
- Chromosome
- 3
- Canonical length
- 232 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Predicted to enable olfactory receptor binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and protein targeting to membrane. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
232 residues, UniProt reviewed canonical sequence.
>Q9BQQ7|RTP3
1 MAGDTEVWKQ MFQELMREVK PWHRWTLRPD KGLLPNVLKP GWMQYQQWTF ARFQCSSCSR
61 NWASAQVLVL FHMNWSEEKS RGQVKMRVFT QRCKKCPQPL FEDPEFTQEN ISRILKNLVF
121 RILKKCYRGR FQLIEEVPMI KDISLEGPHN SDNCEACLQG FCAGPIQVTS LPPSQTPRVH
181 SIYKVEEVVK PWASGENVYS YACQNHICRN LSIFCCCVIL IVIVVIVVKT AILocalizationUniProt · AlphaFold · HPA
Whether an antibody against RTP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 111 nTPM
Expression across tissuesHPA
Tissue
- liver: 111 nTPM
- kidney: 2.5 nTPM
- testis: 0.7 nTPM
- epididymis: 0.5 nTPM
- skeletal muscle: 0.2 nTPM
- thyroid gland: 0.2 nTPM
Single-cell type
- hepatocytes: 104 nCPM
- retinal ganglion cells: 3.9 nCPM
- cardiomyocytes: 2.7 nCPM
- thymic myoid cells: 2.7 nCPM
- early primary spermatocytes: 2.3 nCPM
- differentiating spermatogonia: 1.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- amygdala: 0.2 nTPM
- basal ganglia: 0.2 nTPM
- cerebellum: 0.2 nTPM
- hippocampal formation: 0.2 nTPM
- medulla oblongata: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.53
- gnomAD pLI
- 0.2
- gnomAD missense Z
- 0.34
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- detection of chemical stimulus involved in sensory perception of bitter taste
- protein insertion into membrane
- protein targeting to membrane
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RTP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RTP3 as an antibody target. Whether an autoantibody or antibody against RTP3 could matter depends on whether native RTP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RTP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RTP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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