Seroatlas · Human Serome Atlas

TAGLN3

Transgelin-3

Also known as: NP22, NP25, TAGL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UI15
Gene: TAGLN3
Ensembl: ENSG00000144834
Chromosome: 3
Canonical length: 199 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in actin cytoskeleton and synapse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q9UI15|TAGLN3
     1  MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA HFQKWLMDGT
    61  VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA ETYGVRTTDI FQTVDLWEGK
   121  DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS
   181  NKGASQAGMT GYGMPRQIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAGLN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 475 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 475 nTPM
amygdala: 318 nTPM
cerebellum: 290 nTPM
basal ganglia: 283 nTPM
hypothalamus: 264 nTPM
hippocampal formation: 225 nTPM

Single-cell type

retinal horizontal cells: 166 nCPM
retinal amacrine cells: 101 nCPM
other brain neurons: 95 nCPM
bergmann glia: 94 nCPM
brain excitatory neurons: 90 nCPM
brain inhibitory neurons: 80 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 485 nTPM
hypothalamus: 308 nTPM
white matter: 294 nTPM
pons: 281 nTPM
basal ganglia: 276 nTPM
medulla oblongata: 208 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.18
gnomAD missense Z: 1.57
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin filament binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of TAGLN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TAGLN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAGLN3 as an antibody target. Whether an autoantibody or antibody against TAGLN3 could matter depends on whether native TAGLN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAGLN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAGLN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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