Seroatlas · Human Serome Atlas

TAGLN

Transgelin

Also known as: DKFZp686P11128, SM22, SMCC, TAGL_HUMAN, TAGLN1, WS3-10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01995
Gene
TAGLN
Ensembl
ENSG00000149591
Chromosome
11
Canonical length
201 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Microtubules,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q01995|TAGLN
     1  MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL GFQVWLKNGV
    61  ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA AEDYGVIKTD MFQTVDLFEG
   121  KDMAAVQRTL MALGSLAVTK NDGHYRGDPN WFMKKAQEHK REFTESQLQE GKHVIGLQMG
   181  SNRGASQAGM TGYGRPRQII S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAGLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
13,588 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 13,588 nTPM
  • colon: 8,800 nTPM
  • smooth muscle: 6,628 nTPM
  • endometrium: 6,524 nTPM
  • seminal vesicle: 5,997 nTPM
  • urinary bladder: 4,402 nTPM

Single-cell type

  • smooth muscle cells: 13,251 nCPM
  • vascular smooth muscle cells: 11,546 nCPM
  • hepatic stellate cells: 8,895 nCPM
  • breast myoepithelial cells: 8,848 nCPM
  • decidual stromal cells: 7,514 nCPM
  • pericytes: 3,505 nCPM

Immune cell

  • non-classical monocyte: 64 nTPM
  • intermediate monocyte: 42 nTPM
  • naive B-cell: 5.7 nTPM
  • memory B-cell: 3.9 nTPM
  • myeloid DC: 3.4 nTPM
  • classical monocyte: 3 nTPM

Brain region

  • choroid plexus: 139 nTPM
  • basal ganglia: 80 nTPM
  • cerebral cortex: 77 nTPM
  • thalamus: 72 nTPM
  • medulla oblongata: 65 nTPM
  • pons: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0.09
gnomAD missense Z
0.37
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAGLN as an antibody target. Whether an autoantibody or antibody against TAGLN could matter depends on whether native TAGLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAGLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAGLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAGLN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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