Seroatlas · Human Serome Atlas

SYNDIG1L

Synapse differentiation-inducing gene protein 1-like

Also known as: capucin, DSPC1, IFITMD4, SYN1L_HUMAN, TMEM90A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDD5
Gene: SYNDIG1L
Ensembl: ENSG00000183379
Chromosome: 14
Canonical length: 238 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in Golgi apparatus. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>A6NDD5|SYNDIG1L
     1  MESLSELQNP LLPRSPAHLH GPYPYPETPP SWSCQEKLYS YLLGGAGPAG AHQLLDPGSL
    61  QLAVEAWYRP SCLLGRDKVK EPRAGSCETS FTEDREPQEG PPEQPTGPGQ AAENVTIQTV
   121  SYGVQEELRD QEDDQEEEES DATSTESESE DNFLTLPPRD HLGLTLFSML CCFWPLGIAA
   181  FYFSQGTSKA ISKGDFRLAS TTSRRALFLA TLAIAVGAGL YVAVVVALAA YMSQNGHG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNDIG1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 489 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 489 nTPM
midbrain: 30 nTPM
hypothalamus: 18 nTPM
epididymis: 10 nTPM
hippocampal formation: 7.6 nTPM
cerebral cortex: 6.5 nTPM

Single-cell type

brain inhibitory neurons: 50 nCPM
alveolar cells type 2: 21 nCPM
retinal amacrine cells: 16 nCPM
retinal bipolar cells: 13 nCPM
epididymal principal cells: 4.9 nCPM
other brain neurons: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 992 nTPM
thalamus: 212 nTPM
midbrain: 110 nTPM
amygdala: 91 nTPM
cerebral cortex: 70 nTPM
hypothalamus: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.01
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNDIG1L as an antibody target. Whether an autoantibody or antibody against SYNDIG1L could matter depends on whether native SYNDIG1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNDIG1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNDIG1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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