Seroatlas · Human Serome Atlas

SYCN

Syncollin

Also known as: FLJ27441, INSSA1, SYCN_HUMAN, SYL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VAF6
Gene: SYCN
Ensembl: ENSG00000179751
Chromosome: 19
Canonical length: 134 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to be involved in exocytosis. Predicted to be located in zymogen granule membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q0VAF6|SYCN
     1  MSPLRPLLLA LALASVPCAQ GACPASADLK HSDGTRTCAK LYDKSDPYYE NCCGGAELSL
    61  ESGADLPYLP SNWANTASSL VVAPRCELTV WSRQGKAGKT HKFSAGTYPR LEEYRRGILG
   121  DWSNAISALY CRCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYCN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 26,731 nTPM

Expression across tissuesHPA

Tissue

pancreas: 26,731 nTPM
testis: 28 nTPM
ovary: 4.5 nTPM
heart muscle: 4.2 nTPM
adipose tissue: 4 nTPM
salivary gland: 3.8 nTPM

Single-cell type

pancreatic acinar cells: 15,152 nCPM
pancreatic duct cells: 63 nCPM
sertoli cells: 32 nCPM
monocytes: 16 nCPM
granulosa cells: 15 nCPM
late spermatids: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
amygdala: 0.1 nTPM
white matter: 0.1 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

exocytosis

Cellular components

zymogen granule membrane

Protein domainsUniProt · Pfam · InterPro

Syncollin
Syncollin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYCN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYCN as an antibody target. Whether an autoantibody or antibody against SYCN could matter depends on whether native SYCN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYCN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYCN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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