Seroatlas · Human Serome Atlas

GP2

Pancreatic secretory granule membrane major glycoprotein GP2

Also known as: GP2_HUMAN, ZAP75

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55259
Gene
GP2
Ensembl
ENSG00000169347
Chromosome
16
Canonical length
537 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

537 residues, UniProt reviewed canonical sequence.

>P55259|GP2
     1  MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF
    61  DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW
   121  LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP
   181  RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK
   241  CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT
   301  LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD
   361  QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN
   421  SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS
   481  QVRSEVPAID LARVLDLGPI TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
33,354 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 33,354 nTPM
  • duodenum: 34 nTPM
  • prostate: 33 nTPM
  • kidney: 28 nTPM
  • stomach: 26 nTPM
  • gallbladder: 18 nTPM

Single-cell type

  • pancreatic acinar cells: 20,522 nCPM
  • prostatic glandular cells: 526 nCPM
  • pancreatic duct cells: 199 nCPM
  • loop of henle epithelial cells: 160 nCPM
  • paneth cells: 54 nCPM
  • cholangiocytes: 48 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • midbrain: 2.1 nTPM
  • cerebellum: 2 nTPM
  • choroid plexus: 1.6 nTPM
  • cerebral cortex: 1.5 nTPM
  • white matter: 1.5 nTPM
  • medulla oblongata: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GP2.

Disease | AutoantibodyPubMed

Conditions in which antibodies against GP2 are reported. Each links to that disease's full target list.

Showing 2 of 3 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for GP2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

31 publications

Show 20 more of 31 total

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.42
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GP2 as an antibody target. Whether an autoantibody or antibody against GP2 could matter depends on whether native GP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GP2 is annotated at the cell surface, where native GP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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