Seroatlas · Human Serome Atlas

SVOPL

Putative transporter SVOPL

Also known as: MGC46715, SVOPL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N434
Gene: SVOPL
Ensembl: ENSG00000157703
Chromosome: 7
Canonical length: 492 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q8N434|SVOPL
     1  MATKPTEPVT ILSLRKLSLG TAEPQVKEPK TFTVEDAVET IGFGRFHIAL FLIMGSTGVV
    61  EAMEIMLIAV VSPVIRCEWQ LENWQVALVT TMVFFGYMVF SILFGLLADR YGRWKILLIS
   121  FLWGAYFSLL TSFAPSYIWF VFLRTMVGCG VSGHSQGLII KTEFLPTKYR GYMLPLSQVF
   181  WLAGSLLIIG LASVIIPTIG WRWLIRVASI PGIILIVAFK FIPESARFNV STGNTRAALA
   241  TLERVAKMNR SVMPEGKLVE PVLEKRGRFA DLLDAKYLRT TLQIWVIWLG ISFAYYGVIL
   301  ASAELLERDL VCGSKSDSAV VVTGGDSGES QSPCYCHMFA PSDYRTMIIS TIGEIALNPL
   361  NILGINFLGR RLSLSITMGC TALFFLLLNI CTSSAGLIGF LFMLRALVAA NFNTVYIYTA
   421  EVYPTTMRAL GMGTSGSLCR IGAMVAPFIS QVLMSASILG ALCLFSSVCV VCAISAFTLP
   481  IETKGRALQQ IK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SVOPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 8.6 nTPM
salivary gland: 5 nTPM
parathyroid gland: 3.9 nTPM
kidney: 3.4 nTPM
retina: 3 nTPM
adrenal gland: 1.9 nTPM

Single-cell type

renal collecting duct intercalated cells: 184 nCPM
oocytes: 166 nCPM
distal convoluted tubule cells: 91 nCPM
renal connecting tubule cells: 71 nCPM
ependymal cells: 64 nCPM
renal collecting duct principal cells: 64 nCPM

Immune cell

eosinophil: 2.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 5.4 nTPM
midbrain: 1.8 nTPM
medulla oblongata: 1.6 nTPM
white matter: 1.5 nTPM
thalamus: 1.3 nTPM
amygdala: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SVOPL as an antibody target. Whether an autoantibody or antibody against SVOPL could matter depends on whether native SVOPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SVOPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SVOPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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