Seroatlas · Human Serome Atlas

SUOX

Sulfite oxidase, mitochondrial

Also known as: SUOX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51687
Gene
SUOX
Ensembl
ENSG00000139531
Chromosome
12
Canonical length
545 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>P51687|SUOX
     1  MLLLHRAVVL RLQQACRLKS IPSRICIQAC STNDSFQPQR PSLTFSGDNS STQGWRVMGT
    61  LLGLGAVLAY QDHRCRAAQE STHIYTKEEV SSHTSPETGI WVTLGSEVFD VTEFVDLHPG
   121  GPSKLMLAAG GPLEPFWALY AVHNQSHVRE LLAQYKIGEL NPEDKVAPTV ETSDPYADDP
   181  VRHPALKVNS QRPFNAEPPP ELLTENYITP NPIFFTRNHL PVPNLDPDTY RLHVVGAPGG
   241  QSLSLSLDDL HNFPRYEITV TLQCAGNRRS EMTQVKEVKG LEWRTGAIST ARWAGARLCD
   301  VLAQAGHQLC ETEAHVCFEG LDSDPTGTAY GASIPLARAM DPEAEVLLAY EMNGQPLPRD
   361  HGFPVRVVVP GVVGARHVKW LGRVSVQPEE SYSHWQRRDY KGFSPSVDWE TVDFDSAPSI
   421  QELPVQSAIT EPRDGETVES GEVTIKGYAW SGGGRAVIRV DVSLDGGLTW QVAKLDGEEQ
   481  RPRKAWAWRL WQLKAPVPAG QKELNIVCKA VDDGYNVQPD TVAPIWNLRG VLSNAWHRVH
   541  VYVSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUOX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • liver: 70 nTPM
  • parathyroid gland: 46 nTPM
  • skeletal muscle: 43 nTPM
  • kidney: 38 nTPM
  • adrenal gland: 33 nTPM
  • epididymis: 31 nTPM

Single-cell type

  • hepatocytes: 56 nCPM
  • cytotrophoblasts: 45 nCPM
  • syncytiotrophoblasts: 42 nCPM
  • migrating cytotrophoblasts: 35 nCPM
  • esophageal apical cells: 31 nCPM
  • adrenal cortex cells: 30 nCPM

Immune cell

  • eosinophil: 30 nTPM
  • intermediate monocyte: 19 nTPM
  • NK-cell: 17 nTPM
  • non-classical monocyte: 16 nTPM
  • myeloid DC: 16 nTPM
  • classical monocyte: 13 nTPM

Brain region

  • white matter: 36 nTPM
  • choroid plexus: 36 nTPM
  • thalamus: 33 nTPM
  • cerebellum: 33 nTPM
  • cerebral cortex: 32 nTPM
  • pons: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SUOX.

Disease | AllUniProt

Conditions SUOX is implicated in, by any mechanism.

  • Sulfite oxidase deficiency, isolated (ISOD) MIM:272300

Disease | GeneticClinVar

79 pathogenic / likely-pathogenic of 517 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUOX as an antibody target. Whether an autoantibody or antibody against SUOX could matter depends on whether native SUOX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUOX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUOX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUOX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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