Cytochrome b5, heme-binding site

Definition

Cytochromes b5 are ubiquitous electron transport proteins found in animals, plants and yeasts PMID:2752049. The microsomal and mitochondrial variants are membrane-bound, while those from erythrocytes and other animal tissues are water-soluble [[cite:PMID:4030743], [cite:PMID:8439576]]. The 3D structure of bovine cyt b5 is known, the fold belonging to the α+β class, with 5 strands and 5 short helices forming a framework for supporting a central haem group PMID:1167544. The cytochrome b5 domain is similar to that of a number of oxidoreductases, such as plant and fungal nitrate reductases, sulphite oxidase, yeast flavocytochrome b2 (L-lactate dehydrogenase) and plant cyt b5/acyl lipid desaturase fusion protein. This conserved site includes the first of the two histidine heme ligands, which are found in the heme-binding domain of cytochrome b5 family.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CYB5A
• CYB5B
• CYB5R4
• FA2H
• SUOX