Seroatlas · Human Serome Atlas

STRA8

Stimulated by retinoic acid gene 8 protein homolog

Also known as: STRA8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7C7
Gene
STRA8
Ensembl
ENSG00000146857
Chromosome
7
Canonical length
330 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q7Z7C7|STRA8
     1  MGKIDVDKIL FFNQEIRLWQ LIMATPEENS NPHDRATPQL PAQLQELEHR VARRRLSQAR
    61  HRATLAALFN NLRKTVYSQS DLIASKWQVL NKAKSHIPEL EQTLDNLLKL KASFNLEDGH
   121  ASSLEEVKKE YASMYSGNDS FPQNGSSPWY LNFYKQTMDL LTGSGIITPQ EAALPIVSAA
   181  ISHLWQNLSE ERKASLRQAW AQKHRGPATL AEACREPACA EGSVKDSGVD SQGASCSLVS
   241  TPEEILFEDA FDVASFLDKS EVPSTSSSSS VLASCNPENP EEKFQLYMQI INFFKGLSCA
   301  NTQVKQEASF PVDEEMIMLQ CTETFDDEDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.3 nTPM
  • kidney: 0.6 nTPM
  • choroid plexus: 0.4 nTPM
  • skin: 0.4 nTPM
  • placenta: 0.3 nTPM
  • basal ganglia: 0.2 nTPM

Single-cell type

  • differentiating spermatogonia: 21 nCPM
  • oocytes: 14 nCPM
  • epicardial cells: 14 nCPM
  • early primary spermatocytes: 11 nCPM
  • cytotrophoblasts: 5.9 nCPM
  • choroid plexus epithelial cells: 4.5 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 20 nTPM
  • hippocampal formation: 2.5 nTPM
  • white matter: 1.3 nTPM
  • pons: 1.2 nTPM
  • amygdala: 1.1 nTPM
  • medulla oblongata: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STRA8.

Disease | ImmuneIEDB

Conditions an epitope on STRA8 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
1.28
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRA8 as an antibody target. Whether an autoantibody or antibody against STRA8 could matter depends on whether native STRA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRA8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STRA8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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