Seroatlas · Human Serome Atlas

MEIOSIN

Meiosis initiator protein

Also known as: BHMG1, HMGDC, MEIOS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JSJ3
Gene: MEIOSIN
Ensembl: ENSG00000237452
Chromosome: 19
Canonical length: 638 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and protein dimerization activity. Predicted to be involved in several processes, including activation of meiosis; cellular response to retinoic acid; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>C9JSJ3|MEIOSIN
     1  MFGSSRYLGS SEQPRANSLG PSDRTLVLCS LVEGEDKVNP SEPHGLRMEE KWLLKGKLRN
    61  QRNQNKLLSP NKKQRKNHTS KLQELALLLP IALKTGTKKL TKKEILVHVL QYIQYLQRNI
   121  DAAKALFKCH ITTGEGGLAG LGQKPAWGPA RRRRHSTPSS SPSSQKSCLQ GACQKPRKKK
   181  LTQASESQTR TPKPRRSLAL NKPEKLVAPS PDQKGSGTGG TTTPPRCPDS CGHPRPASSS
   241  PPGDRKGGQS QLTLLDLAED TIHCDISSCW CQGSVQDDAP FPALLAQEDV ARIHFLNKTQ
   301  PHPRQKLVFY DSSEDVDKGS LDADPWLPAW TPENSPQGSP LFLGPPQIDV WSGTGHPSEI
   361  LGLSPSLFSS PGKLLPDEIL EDDMEYLTQA AFFEEVCLDL ESSPSAYTQE APQEKDTASK
   421  APKDPPESHS LHRSSVSLDH CYLSLSGNSK APSSSSSSSS SSSSSEDSDS EPLWKQREDM
   481  QANPVGTPGS SEEDEDTTWT PTRLASPLLA AEKKATKGQV ARAPVKPKEK KKGPCPPQMK
   541  KKCVNGFIMF CRMNRKQYIR SCPGTASTAA TKELAQLWRV MTQQERRPYC TKARRFSRQH
   601  NRIVKQDGSS SEAEDWETPK PFYQLLAEKA LPLPPHLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIOSIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

testis: 7.5 nTPM
heart muscle: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early primary spermatocytes: 82 nCPM
differentiating spermatogonia: 35 nCPM
foveolar cells: 2.7 nCPM
respiratory ionocytes: 2.5 nCPM
epicardial cells: 2.3 nCPM
early spermatids: 2.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 1.1 nTPM
hypothalamus: 0.7 nTPM
amygdala: 0.4 nTPM
cerebral cortex: 0.4 nTPM
pons: 0.4 nTPM
hippocampal formation: 0.3 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEIOSIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STRA8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEIOSIN as an antibody target. Whether an autoantibody or antibody against MEIOSIN could matter depends on whether native MEIOSIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEIOSIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEIOSIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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