Seroatlas · Human Serome Atlas

STPG2

Sperm-tail PG-rich repeat-containing protein 2

Also known as: C4orf37, MGC46496, STPG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N412
Gene: STPG2
Ensembl: ENSG00000163116
Chromosome: 4
Canonical length: 459 aa
Protein class: Predicted intracellular proteins
Subcellular location: Principal piece

OverviewNCBI Gene

No narrative summary is available for STPG2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q8N412|STPG2
     1  MYDRAPRLLK LAEGGSTEAH VGPGSYQVPF LKQQATGSNA PFLSLTARES TFTIASSIEK
    61  AVPGPGHYNV SEAQKISRSP TLTRSVDVPS IPSCGKSYGY HINDDGSIIK CFPPACDSTL
   121  GPAYYKPQFD VSNATLKYKG IHFGNSSGRQ ELPKKSGPGP GQYDIVQKKT SYYENVNIKR
   181  DQQQNYCSFI PRLYEIIVLQ EKKKRFLPMK SITPAPGTYN EPRTALKSLK KTSGLKNIPF
   241  GQSAVRFTQD IRTEEMPGPG FYNVLNNTII ASVRNICSKK QKKSAFGSSV PRTFFSVQKE
   301  ACATPGPADY QEFWHSQGVG ISDELPNLTN KYAAFLSRAK RTMKVPDMVI PAPGSYDVHK
   361  SYEMSQVKHK YMPPRSLVAK RKHASFLSAT PRCLEKVTDG PGPAAYNPVL RKSCPIPLFV
   421  KASKRFEESK EITPGPATYE ISQEKKKGNL IGEMAADIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STPG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

testis: 1.8 nTPM
retina: 0.8 nTPM
kidney: 0.5 nTPM
epididymis: 0.4 nTPM
pituitary gland: 0.4 nTPM
thyroid gland: 0.4 nTPM

Single-cell type

proximal tubule cells: 571 nCPM
renal collecting duct intercalated cells: 546 nCPM
loop of henle epithelial cells: 422 nCPM
distal convoluted tubule cells: 384 nCPM
renal connecting tubule cells: 278 nCPM
thyrotrophs: 271 nCPM

Immune cell

naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 5.8 nTPM
basal ganglia: 4.6 nTPM
medulla oblongata: 4.5 nTPM
pons: 4.5 nTPM
hypothalamus: 4 nTPM
midbrain: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -0.5
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STPG2 as an antibody target. Whether an autoantibody or antibody against STPG2 could matter depends on whether native STPG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STPG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STPG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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