STOX2

Protein identityUniProt · HPA

UniProt accession

Q9P2F5

Gene

STOX2

Ensembl

ENSG00000173320

Chromosome

4

Canonical length

926 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a Storkhead-box_winged-helix domain containing protein. This protein is differentially expressed in decidual tissue and may be involved in the susceptibility to pre-eclampsia with fetal growth restriction. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

926 residues, UniProt reviewed canonical sequence.

>Q9P2F5|STOX2
     1  MKKTRSTTLR RAWPSSDFSD RASDRMRSRS EKDYRLHKRF PAAFAPQASR GYMTSGDVSP
    61  ISMSPISQSQ FIPLGEILCL AISAMNSARK PVTQEALMEH LTTCFPGVPT PSQEILRHTL
   121  NTLVRERKIY PTPDGYFIVT PQTYFITPSL IRTNSKWYHL DERIPDRSQC TSPQPGTITP
   181  SASGCVRERT LPRNHCDSCH CCREDVHSTH APTLQRKSAK DCKDPYCPPS LCQVPPTEKS
   241  KSTVNFSYKT ETLSKPKDSE KQSKKFGLKL FRLSFKKDKT KQLANFSAQF PPEEWPLRDE
   301  DTPATIPREV EMEIIRRINP DLTVENVMRH TALMKKLEEE KAQRSKAGSS AHHSGRSKKS
   361  RTHRKSHGKS RSHSKTRVSK GDPSDGSHLD IPAEREYDFC DPLTRVPREG CFIIEHKGDN
   421  FIMHSNTNVL ESHFPMTPEW DVSGELAKRR TEMPFPEPSR GSSHSKVHRS HSHTQDRRSR
   481  NERSNKAKER SRSMDNSKGP LGASSLGTPE DLAEGCSQDD QTPSQSYIDD STLRPAQTVS
   541  LQRAHISSTS YKEVCIPEIV SGSKEPSSAC SLLEPGKPPE SLPSYGELNS CPTKTATDDY
   601  FQCNTSSETV LTAPSPLGKN KEDHDTLTLA EGVKKLSPSD RQVPHSSREP VGHKEESPKG
   661  PGGGPAASGG VAEGIANGRL VQHHGAEPSS LDKRKEIFSK DTLFKPLHST LSVNSYHKSS
   721  LSLLKSHPKT PADTLPGRCE KLEPSLGTSA AQAMPASQRQ QESGGNQEAS FDYYNVSDDD
   781  DSEEGANKNT EEEKNREDVG TMQWLLEREK ERDLQRKFEK NLTLLAPKET DSSSNQRATH
   841  SARLDSMDSS SITVDSGFNS PRTRESLASN TSSIVESNRR QNPALSPAHG GAGPAFNFRA
   901  SAEPPTNEAE KLQKPSNCLQ ASVTSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STOX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

9.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0.48

gnomAD missense Z

1.33

DepMap mean gene effect

0.19

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• embryo development ending in birth or egg hatching
• maternal placenta development
• regulation of transcription by RNA polymerase II
• response to bacterium

Molecular functions

• DNA-binding transcription factor activity
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Storkhead-box protein, winged-helix domain
• Storkhead-box protein 1/2
• Winged helix Storkhead-box1 domain

InteractionsUniProt · HPA

Protein binding partners of STOX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DYNLL1