STARD3

Protein identityUniProt · HPA

UniProt accession

Q14849

Gene

STARD3

Ensembl

ENSG00000131748

Chromosome

17

Canonical length

445 aa

Protein class

Cancer-related genes, Metabolic proteins, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Endoplasmic reticulum,Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q14849|STARD3
     1  MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR RTFCLFVTFD
    61  LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV LAFFRFSGLL LGYAVLRLRH
   121  WWVIAVTTLV SSAFLIVKVI LSELLSKGAF GYLLPIVSFV LAWLETWFLD FKVLPQEAEE
   181  ERWYLAAQVA VARGPLLFSG ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR
   241  QGKEATAVVD QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV
   301  ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV RRIERRRDRY
   361  LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC TFVWILNTDL KGRLPRYLIH
   421  QSLAATMFEF AFHLRQRISE LGARA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

31 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.67

gnomAD pLI

0

gnomAD missense Z

0.91

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol metabolic process
• cholesterol transport
• lipid metabolic process
• mitochondrial transport
• progesterone biosynthetic process
• steroid metabolic process
• vesicle tethering to endoplasmic reticulum

Molecular functions

• cholesterol binding
• cholesterol transfer activity
• protein homodimerization activity

Cellular components

• cytoplasm
• cytosol
• endoplasmic reticulum-endosome membrane contact site
• endosome
• late endosome membrane
• lysosomal membrane
• mitochondrion
• nucleoplasm
• organelle membrane contact site

Protein domainsUniProt · Pfam · InterPro

• Steroidogenic acute regulatory protein-like
• START domain
• MENTAL domain
• START-like domain superfamily
• StAR-related Lipid Transfer (STARD3)
• START domain
• Cholesterol-capturing domain
• StAR-related lipid transfer protein 3, C-terminal

KeywordsUniProt

• Endosome
• Lipid transport
• Lipid-binding
• Membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of STARD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MOSPD2