Seroatlas · Human Serome Atlas

MOSPD2

Motile sperm domain-containing protein 2

Also known as: MGC26706, MSPD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHP6
Gene
MOSPD2
Ensembl
ENSG00000130150
Chromosome
X
Canonical length
518 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables FFAT motif binding activity. Involved in lipid droplet formation; positive regulation of leukocyte chemotaxis; and protein homooligomerization. Located in endoplasmic reticulum membrane; endoplasmic reticulum-endosome membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q8NHP6|MOSPD2
     1  MAENHAQNKA KLISETRRRF EAEYVTDKSD KYDARDVERL QQDDNWVESY LSWRHNIVDE
    61  TLKMLDESFQ WRKEISVNDL NESSIPRWLL EIGVIYLHGY DKEGNKLFWI RVKYHVKDQK
   121  TILDKKKLIA FWLERYAKRE NGKPVTVMFD LSETGINSID MDFVRFIINC FKVYYPKYLS
   181  KIVIFDMPWL MNAAFKIVKT WLGPEAVSLL KFTSKNEVQD YVSVEYLPPH MGGTDPFKYS
   241  YPPLVDDDFQ TPLCENGPIT SEDETSSKED IESDGKETLE TISNEEQTPL LKKINPTEST
   301  SKAEENEKVD SKVKAFKKPL SVFKGPLLHI SPAEELYFGS TESGEKKTLI VLTNVTKNIV
   361  AFKVRTTAPE KYRVKPSNSS CDPGASVDIV VSPHGGLTVS AQDRFLIMAA EMEQSSGTGP
   421  AELTQFWKEV PRNKVMEHRL RCHTVESSKP NTLTLKDNAF NMSDKTSEDI CLQLSRLLES
   481  NRKLEDQVQR CIWFQQLLLS LTMLLLAFVT SFFYLLYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOSPD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 27 nTPM
  • skin: 18 nTPM
  • placenta: 15 nTPM
  • thyroid gland: 14 nTPM
  • lung: 14 nTPM
  • spleen: 13 nTPM

Single-cell type

  • neutrophils: 206 nCPM
  • oligodendrocytes: 128 nCPM
  • neutrophil progenitors: 108 nCPM
  • adrenal medulla cells: 53 nCPM
  • monocytes: 46 nCPM
  • monocyte progenitors: 45 nCPM

Immune cell

  • neutrophil: 54 nTPM
  • non-classical monocyte: 16 nTPM
  • classical monocyte: 15 nTPM
  • intermediate monocyte: 14 nTPM
  • basophil: 12 nTPM
  • eosinophil: 6.7 nTPM

Brain region

  • white matter: 158 nTPM
  • medulla oblongata: 116 nTPM
  • pons: 103 nTPM
  • cerebellum: 103 nTPM
  • cerebral cortex: 102 nTPM
  • basal ganglia: 100 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
1.66
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOSPD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOSPD2 as an antibody target. Whether an autoantibody or antibody against MOSPD2 could matter depends on whether native MOSPD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOSPD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOSPD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MOSPD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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