Seroatlas · Human Serome Atlas

ST7

Suppressor of tumorigenicity 7 protein

Also known as: ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, ST7_HUMAN, TSG7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRC1
Gene: ST7
Ensembl: ENSG00000004866
Chromosome: 7
Canonical length: 585 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q9NRC1|ST7
     1  MAEAATGFLE QLKSCIVWSW TYLWTVWFFI VLFLVYILRV PLKINDNLST VSMFLNTLTP
    61  KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN
   121  GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS
   181  DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT
   241  AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR
   301  RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD
   361  ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL
   421  LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG
   481  HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM
   541  GVFAKAMIDI FCSAEFRDWN CKSIFMRVED ELEIPPAPQS QHFQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

liver: 39 nTPM
epididymis: 34 nTPM
pancreas: 31 nTPM
cerebellum: 29 nTPM
kidney: 27 nTPM
thyroid gland: 27 nTPM

Single-cell type

proximal tubule cells: 356 nCPM
renal collecting duct intercalated cells: 301 nCPM
renal connecting tubule cells: 209 nCPM
early spermatids: 182 nCPM
renal collecting duct principal cells: 158 nCPM
loop of henle epithelial cells: 143 nCPM

Immune cell

T-reg: 10 nTPM
gdT-cell: 7.3 nTPM
NK-cell: 7.1 nTPM
memory CD8 T-cell: 6.2 nTPM
myeloid DC: 5.7 nTPM
plasmacytoid DC: 5.6 nTPM

Brain region

cerebellum: 102 nTPM
hypothalamus: 45 nTPM
cerebral cortex: 44 nTPM
basal ganglia: 44 nTPM
hippocampal formation: 40 nTPM
white matter: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ST7.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 3.38
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ST7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DCAF4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST7 as an antibody target. Whether an autoantibody or antibody against ST7 could matter depends on whether native ST7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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