Seroatlas · Human Serome Atlas

SSTR2

Somatostatin receptor type 2

Also known as: SSR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30874
Gene
SSTR2
Ensembl
ENSG00000180616
Chromosome
17
Canonical length
369 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>P30874|SSTR2
     1  MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY FVVCIIGLCG
    61  NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA MQVALVHWPF GKAICRVVMT
   121  VDGINQFTSI FCLTVMSIDR YLAVVHPIKS AKWRRPRTAK MITMAVWGVS LLVILPIMIY
   181  AGLRSNQWGR SSCTINWPGE SGAWYTGFII YTFILGFLVP LTIICLCYLF IIIKVKSSGI
   241  RVGSSKRKKS EKKVTRMVSI VVAVFIFCWL PFYIFNVSSV SMAISPTPAL KGMFDFVVVL
   301  TYANSCANPI LYAFLSDNFK KSFQNVLCLV KVSGTDDGER SDSKQDKSRL NETTETQRTL
   361  LNGDLQTSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSTR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 18 nTPM
  • cerebral cortex: 13 nTPM
  • basal ganglia: 6.6 nTPM
  • spleen: 5.7 nTPM
  • kidney: 5.4 nTPM
  • hippocampal formation: 5.3 nTPM

Single-cell type

  • proximal tubule cells: 12 nCPM
  • papillary tip epithelial cells: 5.3 nCPM
  • renal collecting duct principal cells: 4.6 nCPM
  • neuroendocrine cells: 3.5 nCPM
  • pericytes: 3.2 nCPM
  • loop of henle epithelial cells: 2.7 nCPM

Immune cell

  • basophil: 1.2 nTPM
  • neutrophil: 1.1 nTPM
  • eosinophil: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • gdT-cell: 0.2 nTPM

Brain region

  • hippocampal formation: 25 nTPM
  • pons: 25 nTPM
  • basal ganglia: 24 nTPM
  • cerebral cortex: 24 nTPM
  • cerebellum: 21 nTPM
  • white matter: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.44
gnomAD missense Z
1.04
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSTR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSTR2 as an antibody target. Whether an autoantibody or antibody against SSTR2 could matter depends on whether native SSTR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSTR2 is annotated at the cell surface, where native SSTR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SSTR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SSTR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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