Seroatlas · Human Serome Atlas

SSR2

Translocon-associated protein subunit beta

Also known as: SSRB_HUMAN, TLAP, TRAPB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P43308
Gene: SSR2
Ensembl: ENSG00000163479
Chromosome: 1
Canonical length: 183 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>P43308|SSR2
     1  MRLLSFVVLA LFAVTQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG SSAALDVELS
    61  DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA GYFNFTSATI TYLAQEDGPV
   121  VIGSTSAPGQ GGILAQREFD RRFSPHFLDW AAFGVMTLPS IGIPLLLWYS SKRKYDTPKT
   181  KKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 497 nTPM

Expression across tissuesHPA

Tissue

pancreas: 497 nTPM
epididymis: 432 nTPM
ovary: 369 nTPM
adrenal gland: 284 nTPM
salivary gland: 276 nTPM
cervix: 265 nTPM

Single-cell type

extravillous trophoblasts: 1,021 nCPM
decidual stromal cells: 822 nCPM
epididymal principal cells: 696 nCPM
syncytiotrophoblasts: 678 nCPM
plasma cells: 658 nCPM
migrating cytotrophoblasts: 550 nCPM

Immune cell

total PBMC: 1,071 nTPM
basophil: 676 nTPM
MAIT T-cell: 472 nTPM
naive CD4 T-cell: 444 nTPM
memory CD4 T-cell: 438 nTPM
memory CD8 T-cell: 422 nTPM

Brain region

choroid plexus: 72 nTPM
thalamus: 65 nTPM
hypothalamus: 65 nTPM
basal ganglia: 64 nTPM
white matter: 62 nTPM
cerebral cortex: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.21
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Translocon-associated protein subunit beta
Translocon-associated protein beta (TRAPB)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STING1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSR2 as an antibody target. Whether an autoantibody or antibody against SSR2 could matter depends on whether native SSR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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