SS18L2
SS18-like protein 2
Also known as: KIAA-iso, S18L2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UHA2
- Gene
- SS18L2
- Ensembl
- ENSG00000008324
- Chromosome
- 3
- Canonical length
- 77 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Mitochondria
OverviewNCBI Gene
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]
Canonical amino-acid sequenceUniProt
77 residues, UniProt reviewed canonical sequence.
>Q9UHA2|SS18L2
1 MSVAFVPDWL RGKAEVNQET IQRLLEENDQ LIRCIVEYQN KGRGNECVQY QHVLHRNLIY
61 LATIADASPT STSKAMELocalizationUniProt · AlphaFold · HPA
Whether an antibody against SS18L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 33 nTPM
Expression across tissuesHPA
Tissue
- lymph node: 33 nTPM
- bone marrow: 32 nTPM
- tonsil: 28 nTPM
- spinal cord: 28 nTPM
- basal ganglia: 28 nTPM
- cerebellum: 27 nTPM
Single-cell type
- ocular epithelial cells: 130 nCPM
- esophageal basal cells: 116 nCPM
- enterocytes: 115 nCPM
- suprabasal keratinocytes: 113 nCPM
- esophageal suprabasal cells: 103 nCPM
- breast hormone-responsive cells: 102 nCPM
Immune cell
- T-reg: 140 nTPM
- MAIT T-cell: 121 nTPM
- memory B-cell: 121 nTPM
- memory CD4 T-cell: 117 nTPM
- memory CD8 T-cell: 106 nTPM
- naive B-cell: 105 nTPM
Brain region
- white matter: 19 nTPM
- cerebral cortex: 15 nTPM
- cerebellum: 14 nTPM
- basal ganglia: 14 nTPM
- spinal cord: 13 nTPM
- hypothalamus: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.23
- DepMap mean gene effect
- -2.01
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of SS18L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SS18L2 as an antibody target. Whether an autoantibody or antibody against SS18L2 could matter depends on whether native SS18L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SS18L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SS18L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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