Seroatlas · Human Serome Atlas

SRA1

Steroid receptor RNA activator 1

Also known as: SRA, SRA1_HUMAN, STRAA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HD15
Gene
SRA1
Ensembl
ENSG00000213523
Chromosome
5
Canonical length
224 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Microtubules,Cytokinetic bridge,Primary cilium,Cytosol

OverviewNCBI Gene

Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q9HD15|SRA1
     1  MAELYVKPGN KERGWNDPPQ FSYGLQTQAG GPRRSLLTKR VAAPQDGSPR VPASETSPGP
    61  PPMGPPPPSS KAPRSPPVGS GPASGVEPTS FPVESEAVME DVLRPLEQAL EDCRGHTRKQ
   121  VCDDISRRLA LLQEQWAGGK LSIPVKKRMA LLVQELSSHR WDAADDIHRS LMVDHVTEVS
   181  QWMVGVKRLI AEKRSLFSEE AANEEKSAAT AEKNHTIPGF QQAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 53 nTPM
  • skeletal muscle: 43 nTPM
  • choroid plexus: 40 nTPM
  • pituitary gland: 37 nTPM
  • cerebellum: 36 nTPM
  • testis: 32 nTPM

Single-cell type

  • esophageal apical cells: 277 nCPM
  • syncytiotrophoblasts: 241 nCPM
  • late spermatids: 213 nCPM
  • neutrophils: 209 nCPM
  • late primary spermatocytes: 195 nCPM
  • breast lactating cells: 182 nCPM

Immune cell

  • neutrophil: 239 nTPM
  • total PBMC: 156 nTPM
  • classical monocyte: 155 nTPM
  • intermediate monocyte: 146 nTPM
  • myeloid DC: 146 nTPM
  • non-classical monocyte: 139 nTPM

Brain region

  • cerebellum: 25 nTPM
  • cerebral cortex: 23 nTPM
  • hypothalamus: 20 nTPM
  • white matter: 20 nTPM
  • choroid plexus: 20 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
-0.33
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • SRA1/Sec31
  • Steroid receptor RNA activator 1
  • Steroid receptor RNA activator (SRA1)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRA1 as an antibody target. Whether an autoantibody or antibody against SRA1 could matter depends on whether native SRA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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