Seroatlas · Human Serome Atlas

SPRR2G

Small proline-rich protein 2G

Also known as: SPR2G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYE4
Gene
SPRR2G
Ensembl
ENSG00000159516
Chromosome
1
Canonical length
73 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in keratinocyte differentiation. Predicted to act upstream of or within response to estradiol. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

73 residues, UniProt reviewed canonical sequence.

>Q9BYE4|SPRR2G
     1  MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPYLPPP CPPEHCPPPP CQDKCPPVQP
    61  YPPCQQKYPP KSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRR2G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
929 nTPM

Expression across tissuesHPA

Tissue

  • skin: 929 nTPM
  • tonsil: 26 nTPM
  • vagina: 19 nTPM
  • breast: 13 nTPM
  • cervix: 12 nTPM
  • salivary gland: 9.7 nTPM

Single-cell type

  • suprabasal keratinocytes: 121 nCPM
  • extravillous trophoblasts: 30 nCPM
  • esophageal apical cells: 14 nCPM
  • late spermatids: 13 nCPM
  • early spermatids: 6.6 nCPM
  • basal keratinocytes: 6.1 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 1.7 nTPM
  • medulla oblongata: 0.6 nTPM
  • spinal cord: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • basal ganglia: 0.5 nTPM
  • midbrain: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.35
DepMap mean gene effect
-0.51
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRR2G as an antibody target. Whether an autoantibody or antibody against SPRR2G could matter depends on whether native SPRR2G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRR2G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRR2G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRR2G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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