SPRR2F
Small proline-rich protein 2F
Also known as: SPR2F_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96RM1
- Gene
- SPRR2F
- Ensembl
- ENSG00000244094
- Chromosome
- 1
- Canonical length
- 72 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to be involved in keratinocyte differentiation. Predicted to act upstream of or within response to estradiol. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
72 residues, UniProt reviewed canonical sequence.
>Q96RM1|SPRR2F
1 MSYQQQQCKQ PCQPPPVCPA PKCPEPCPPP KCPEPCPPSK CPQSCPPQQC QQKCPPVTPS
61 PPCQPKCPPK SKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRR2F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 254 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 254 nTPM
- ovary: 111 nTPM
- cervix: 93 nTPM
- tonsil: 66 nTPM
- vagina: 29 nTPM
- salivary gland: 23 nTPM
Single-cell type
- esophageal apical cells: 2,323 nCPM
- granulosa cells: 1,441 nCPM
- ovarian stromal cells: 427 nCPM
- esophageal suprabasal cells: 234 nCPM
- suprabasal keratinocytes: 201 nCPM
- oocytes: 32 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- spinal cord: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0.09
- gnomAD missense Z
- -0.17
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRR2F as an antibody target. Whether an autoantibody or antibody against SPRR2F could matter depends on whether native SPRR2F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRR2F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPRR2F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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