SPRR2E
Small proline-rich protein 2E
Also known as: SPR2E_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P22531
- Gene
- SPRR2E
- Ensembl
- ENSG00000203785
- Chromosome
- 1
- Canonical length
- 72 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]
Canonical amino-acid sequenceUniProt
72 residues, UniProt reviewed canonical sequence.
>P22531|SPRR2E
1 MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKCPPVTPS
61 PPCQPKCPPK SKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRR2E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 1,665 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 1,665 nTPM
- skin: 1,202 nTPM
- cervix: 493 nTPM
- tonsil: 472 nTPM
- vagina: 448 nTPM
- salivary gland: 308 nTPM
Single-cell type
- esophageal apical cells: 26,216 nCPM
- esophageal suprabasal cells: 3,330 nCPM
- suprabasal keratinocytes: 2,188 nCPM
- esophageal basal cells: 422 nCPM
- basal keratinocytes: 115 nCPM
- mast cells: 112 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0.06
- gnomAD missense Z
- -0.32
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRR2E as an antibody target. Whether an autoantibody or antibody against SPRR2E could matter depends on whether native SPRR2E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRR2E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPRR2E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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