Seroatlas · Human Serome Atlas

SPRR2D

Small proline-rich protein 2D

Also known as: SPR2D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P22532
Gene
SPRR2D
Ensembl
ENSG00000163216
Chromosome
1
Canonical length
72 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in female gonad development. Predicted to act upstream of or within response to estradiol. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

72 residues, UniProt reviewed canonical sequence.

>P22532|SPRR2D
     1  MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPSPK CPQPCPPQQC QQKYPPVTPS
    61  PPCQPKCPPK SK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRR2D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
1,961 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 1,961 nTPM
  • cervix: 746 nTPM
  • vagina: 487 nTPM
  • tonsil: 360 nTPM
  • salivary gland: 278 nTPM
  • skin: 185 nTPM

Single-cell type

  • esophageal apical cells: 24,737 nCPM
  • esophageal suprabasal cells: 1,652 nCPM
  • suprabasal keratinocytes: 827 nCPM
  • esophageal basal cells: 244 nCPM
  • ocular epithelial cells: 123 nCPM
  • basal keratinocytes: 53 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 0.2 nTPM
  • cerebellum: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0.02
gnomAD missense Z
-0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRR2D as an antibody target. Whether an autoantibody or antibody against SPRR2D could matter depends on whether native SPRR2D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRR2D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRR2D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRR2D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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