Seroatlas · Human Serome Atlas

SPRR2B

Small proline-rich protein 2B

Also known as: SPR2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35325
Gene
SPRR2B
Ensembl
ENSG00000196805
Chromosome
1
Canonical length
72 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in keratinocyte differentiation. Predicted to act upstream of or within response to estradiol. Predicted to be located in cornified envelope and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

72 residues, UniProt reviewed canonical sequence.

>P35325|SPRR2B
     1  MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS
    61  PPCQPKYPPK SK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRR2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 51 nTPM
  • cervix: 44 nTPM
  • skin: 41 nTPM
  • salivary gland: 16 nTPM
  • tonsil: 15 nTPM
  • vagina: 15 nTPM

Single-cell type

  • esophageal apical cells: 741 nCPM
  • suprabasal keratinocytes: 139 nCPM
  • esophageal suprabasal cells: 16 nCPM
  • mast cells: 7.5 nCPM
  • granulosa cells: 7.3 nCPM
  • basal keratinocytes: 5.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.21

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRR2B as an antibody target. Whether an autoantibody or antibody against SPRR2B could matter depends on whether native SPRR2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRR2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRR2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRR2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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