Seroatlas · Human Serome Atlas

SPNS2

Sphingosine-1-phosphate transporter SPNS2

Also known as: SLC63A2, SPNS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVW8
Gene
SPNS2
Ensembl
ENSG00000183018
Chromosome
17
Canonical length
549 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q8IVW8|SPNS2
     1  MMCLECASAA AGGAEEEEAD AERRRRRRGA QRGAGGSGCC GARGAGGAGV SAAGDEVQTL
    61  SGSVRRAPTG PPGTPGTPGC AATAKGPGAQ QPKPASLGRG RGAAAAILSL GNVLNYLDRY
   121  TVAGVLLDIQ QHFGVKDRGA GLLQSVFICS FMVAAPIFGY LGDRFNRKVI LSCGIFFWSA
   181  VTFSSSFIPQ QYFWLLVLSR GLVGIGEASY STIAPTIIGD LFTKNTRTLM LSVFYFAIPL
   241  GSGLGYITGS SVKQAAGDWH WALRVSPVLG MITGTLILIL VPATKRGHAD QLGDQLKART
   301  SWLRDMKALI RNRSYVFSSL ATSAVSFATG ALGMWIPLYL HRAQVVQKTA ETCNSPPCGA
   361  KDSLIFGAIT CFTGFLGVVT GAGATRWCRL KTQRADPLVC AVGMLGSAIF ICLIFVAAKS
   421  SIVGAYICIF VGETLLFSNW AITADILMYV VIPTRRATAV ALQSFTSHLL GDAGSPYLIG
   481  FISDLIRQST KDSPLWEFLS LGYALMLCPF VVVLGGMFFL ATALFFVSDR ARAEQQVNQL
   541  AMPPASVKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPNS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 50 nTPM
  • kidney: 34 nTPM
  • lung: 27 nTPM
  • skin: 24 nTPM
  • vagina: 22 nTPM
  • cervix: 20 nTPM

Single-cell type

  • esophageal apical cells: 627 nCPM
  • microglia: 150 nCPM
  • renal collecting duct principal cells: 142 nCPM
  • proximal tubule cells: 119 nCPM
  • oligodendrocytes: 102 nCPM
  • vascular endothelial cells: 92 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 72 nTPM
  • white matter: 61 nTPM
  • medulla oblongata: 55 nTPM
  • cerebral cortex: 49 nTPM
  • midbrain: 45 nTPM
  • thalamus: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPNS2.

Disease | AllUniProt

Conditions SPNS2 is implicated in, by any mechanism.

  • Deafness, autosomal recessive, 115 (DFNB115) MIM:618457

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 180 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
-0.07
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPNS2 as an antibody target. Whether an autoantibody or antibody against SPNS2 could matter depends on whether native SPNS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPNS2 is annotated at the cell surface, where native SPNS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SPNS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPNS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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