Seroatlas · Human Serome Atlas

SNRK

SNF-related serine/threonine-protein kinase

Also known as: FLJ20224, HSNFRK, KIAA0096, SNRK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRH2
Gene: SNRK
Ensembl: ENSG00000163788
Chromosome: 3
Canonical length: 765 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane,Cell Junctions

OverviewNCBI Gene

SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q9NRH2|SNRK
     1  MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT KLDTLATGHL
    61  FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM FDYIMKHEEG LNEDLAKKYF
   121  AQIVHAISYC HKLHVVHRDL KPENVVFFEK QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY
   181  SAPEILLGDE YDAPAVDIWS LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPSHVSK
   241  ECKDLITRML QRDPKRRASL EEIENHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ
   301  RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA SPSNIKAQFR
   361  QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAADSVLN GHRSKGLCDS AKKDDLPELA
   421  GPALSTVPPA SLKPTASGRK CLFRVEEDEE EDEEDKKPMS LSTQVVLRRK PSVTNRLTSR
   481  KSAPVLNQIF EEGESDDEFD MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS
   541  SETSDDDSES RRRLDKDSGF TYSWHRRDSS EGPPGSEGDG GGQSKPSNAS GGVDKASPSE
   601  NNAGGGSPSS GSGGNPTNTS GTTRRCAGPS NSMQLASRSA GELVESLKLM SLCLGSQLHG
   661  STKYIIDPQN GLSFSSVKVQ EKSTWKMCIS STGNAGQVPA VGGIKFFSDH MADTTTELER
   721  IKSKNLKNNV LQLPLCEKTI SVNIQRNPKE GLLCASSPAS CCHVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 55 nTPM
thymus: 38 nTPM
adipose tissue: 36 nTPM
placenta: 31 nTPM
spleen: 31 nTPM
cerebellum: 31 nTPM

Single-cell type

neutrophils: 828 nCPM
neutrophil progenitors: 301 nCPM
loop of henle epithelial cells: 275 nCPM
vascular endothelial cells: 251 nCPM
innate lymphoid cells: 197 nCPM
nk-cells: 192 nCPM

Immune cell

neutrophil: 28 nTPM
naive CD8 T-cell: 13 nTPM
MAIT T-cell: 13 nTPM
naive CD4 T-cell: 12 nTPM
NK-cell: 11 nTPM
T-reg: 9.7 nTPM

Brain region

cerebellum: 66 nTPM
pons: 39 nTPM
thalamus: 37 nTPM
cerebral cortex: 36 nTPM
hypothalamus: 35 nTPM
medulla oblongata: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 3.47
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CAMK2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRK as an antibody target. Whether an autoantibody or antibody against SNRK could matter depends on whether native SNRK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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