Seroatlas · Human Serome Atlas

SMIM26

Small integral membrane protein 26

Also known as: LINC00493, LOC388789, SIM26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A096LP01
Gene
SMIM26
Ensembl
ENSG00000232388
Chromosome
20
Canonical length
95 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables protein kinase binding activity and transmembrane transporter binding activity. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>A0A096LP01|SMIM26
     1  MYRNEFTAWY RRMSVVYGIG TWSVLGSLLY YSRTMAKSSV DQKDGSASEV PSELSERPKG
    61  FYVETVVTYK EDFVPNTEKI LNYWKSWTGG PGTEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
231 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 231 nTPM
  • tongue: 199 nTPM
  • choroid plexus: 184 nTPM
  • heart muscle: 132 nTPM
  • ovary: 132 nTPM
  • epididymis: 127 nTPM

Single-cell type

  • parietal cells: 440 nCPM
  • gastric chief cells: 295 nCPM
  • mucous neck cells: 135 nCPM
  • breast secretory cells: 134 nCPM
  • hepatocytes: 111 nCPM
  • enterocytes: 104 nCPM

Immune cell

  • neutrophil: 243 nTPM
  • myeloid DC: 165 nTPM
  • plasmacytoid DC: 158 nTPM
  • memory B-cell: 156 nTPM
  • T-reg: 151 nTPM
  • naive B-cell: 147 nTPM

Brain region

  • choroid plexus: 62 nTPM
  • cerebellum: 59 nTPM
  • white matter: 58 nTPM
  • hypothalamus: 47 nTPM
  • pons: 46 nTPM
  • spinal cord: 46 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small integral membrane protein 26

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMIM26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM26 as an antibody target. Whether an autoantibody or antibody against SMIM26 could matter depends on whether native SMIM26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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