Seroatlas · Human Serome Atlas

SLC25A11

Mitochondrial 2-oxoglutarate/malate carrier protein

Also known as: M2OM_HUMAN, OGC, SLC20A4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02978
Gene
SLC25A11
Ensembl
ENSG00000108528
Chromosome
17
Canonical length
314 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q02978|SLC25A11
     1  MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ LSGEGAKTRE
    61  YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG IYTVLFERLT GADGTPPGFL
   121  LKAVIGMTAG ATGAFVGTPA EVALIRMTAD GRLPADQRRG YKNVFNALIR ITREEGVLTL
   181  WRGCIPTMAR AVVVNAAQLA SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV
   241  DIAKTRIQNM RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
   301  EQMNKAYKRL FLSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
420 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 420 nTPM
  • skeletal muscle: 295 nTPM
  • heart muscle: 219 nTPM
  • choroid plexus: 78 nTPM
  • cerebral cortex: 73 nTPM
  • kidney: 69 nTPM

Single-cell type

  • extravillous trophoblasts: 167 nCPM
  • cytotrophoblasts: 155 nCPM
  • migrating cytotrophoblasts: 136 nCPM
  • esophageal basal cells: 129 nCPM
  • tuft cells: 127 nCPM
  • hofbauer cells: 118 nCPM

Immune cell

  • total PBMC: 186 nTPM
  • intermediate monocyte: 177 nTPM
  • classical monocyte: 171 nTPM
  • non-classical monocyte: 166 nTPM
  • myeloid DC: 161 nTPM
  • NK-cell: 152 nTPM

Brain region

  • cerebellum: 79 nTPM
  • thalamus: 77 nTPM
  • hippocampal formation: 77 nTPM
  • hypothalamus: 71 nTPM
  • midbrain: 69 nTPM
  • cerebral cortex: 66 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC25A11.

Disease | AllUniProt

Conditions SLC25A11 is implicated in, by any mechanism.

  • Pheochromocytoma/paraganglioma syndrome 6 (PPGL6) MIM:618464

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 93 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pheochromocytoma/paraganglioma syndrome 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.53
gnomAD missense Z
2.49
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC25A11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A11 as an antibody target. Whether an autoantibody or antibody against SLC25A11 could matter depends on whether native SLC25A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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