Seroatlas · Human Serome Atlas

SLU7

Pre-mRNA-splicing factor SLU7

Also known as: 9G8, SLU7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95391
Gene: SLU7
Ensembl: ENSG00000164609
Chromosome: 5
Canonical length: 586 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>O95391|SLU7
     1  MSATVVDAVN AAPLSGSKEM SLEEPKKMTR EDWRKKKELE EQRKLGNAPA EVDEEGKDIN
    61  PHIPQYISSV PWYIDPSKRP TLKHQRPQPE KQKQFSSSGE WYKRGVKENS IITKYRKGAC
   121  ENCGAMTHKK KDCFERPRRV GAKFTGTNIA PDEHVQPQLM FDYDGKRDRW NGYNPEEHMK
   181  IVEEYAKVDL AKRTLKAQKL QEELASGKLV EQANSPKHQW GEEEPNSQME KDHNSEDEDE
   241  DKYADDIDMP GQNFDSKRRI TVRNLRIRED IAKYLRNLDP NSAYYDPKTR AMRENPYANA
   301  GKNPDEVSYA GDNFVRYTGD TISMAQTQLF AWEAYDKGSE VHLQADPTKL ELLYKSFKVK
   361  KEDFKEQQKE SILEKYGGQE HLDAPPAELL LAQTEDYVEY SRHGTVIKGQ ERAVACSKYE
   421  EDVKIHNHTH IWGSYWKEGR WGYKCCHSFF KYSYCTGEAG KEIVNSEECI INEITGEESV
   481  KKPQTLMELH QEKLKEEKKK KKKKKKKHRK SSSDSDDEEK KHEKLKKALN AEEARLLHVK
   541  ETMQIDERKR PYNSMYETRE PTEEEMEAYR MKRQRPDDPM ASFLGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLU7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 46 nTPM
skeletal muscle: 33 nTPM
tongue: 31 nTPM
cerebral cortex: 31 nTPM
thyroid gland: 30 nTPM
tonsil: 29 nTPM

Single-cell type

oocytes: 207 nCPM
late primary spermatocytes: 197 nCPM
neutrophils: 194 nCPM
esophageal apical cells: 155 nCPM
syncytiotrophoblasts: 126 nCPM
early spermatids: 104 nCPM

Immune cell

neutrophil: 54 nTPM
basophil: 50 nTPM
eosinophil: 39 nTPM
non-classical monocyte: 37 nTPM
NK-cell: 34 nTPM
memory B-cell: 30 nTPM

Brain region

cerebral cortex: 42 nTPM
white matter: 38 nTPM
cerebellum: 37 nTPM
midbrain: 36 nTPM
basal ganglia: 35 nTPM
hypothalamus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 1.99
DepMap mean gene effect: -1.37
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

pre-mRNA 3'-splice site binding
zinc ion binding
second spliceosomal transesterification activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Pre-mRNA-splicing factor SLU7 domain
Pre-mRNA-splicing factor SLU7
Pre-mRNA splicing Prp18-interacting factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLU7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLU7 as an antibody target. Whether an autoantibody or antibody against SLU7 could matter depends on whether native SLU7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLU7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLU7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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