Seroatlas · Human Serome Atlas

PPIL3

Peptidyl-prolyl cis-trans isomerase-like 3

Also known as: CyPJ, PPIL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2H8
Gene: PPIL3
Ensembl: ENSG00000240344
Chromosome: 2
Canonical length: 161 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q9H2H8|PPIL3
     1  MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC IFHRNIKGFM VQTGDPTGTG
    61  RGGNSIWGKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ FFITYGKQPH LDMKYTVFGK
   121  VIDGLETLDE LEKLPVNEKT YRPLNDVHIK DITIHANPFA Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

ovary: 25 nTPM
tonsil: 24 nTPM
thymus: 24 nTPM
lymph node: 23 nTPM
spinal cord: 20 nTPM
bone marrow: 19 nTPM

Single-cell type

late primary spermatocytes: 141 nCPM
gastric chief cells: 83 nCPM
megakaryocytes: 74 nCPM
extravillous trophoblasts: 73 nCPM
migrating cytotrophoblasts: 71 nCPM
decidual stromal cells: 68 nCPM

Immune cell

memory B-cell: 34 nTPM
myeloid DC: 30 nTPM
basophil: 29 nTPM
T-reg: 29 nTPM
NK-cell: 29 nTPM
naive CD8 T-cell: 26 nTPM

Brain region

white matter: 13 nTPM
cerebellum: 12 nTPM
hypothalamus: 12 nTPM
cerebral cortex: 11 nTPM
pons: 11 nTPM
medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.9
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

peptidyl-prolyl cis-trans isomerase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPIL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIL3 as an antibody target. Whether an autoantibody or antibody against PPIL3 could matter depends on whether native PPIL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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