Seroatlas · Human Serome Atlas

SLF1

SMC5-SMC6 complex localization factor protein 1

Also known as: ANKRD32, BRCTD1, BRCTx, DKFZp564C0469, DKFZp761C121, SLF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQI6
Gene: SLF1
Ensembl: ENSG00000133302
Chromosome: 5
Canonical length: 1058 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in nucleoplasm and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1058 residues, UniProt reviewed canonical sequence.

>Q9BQI6|SLF1
     1  MEDGTPKHII QMTGFKMEEK EALVKLLLKL DCTFIKSEKY KNCTHLIAER LCKSEKFLAA
    61  CAAGKWILTK DYIIHSAKSG RWLDETTYEW GYKIEKDSRY SPQMQSAPKR WREELKRTGA
   121  PGAFHRWKVV LLVRTDKRSD SLIRVLEAGK ANVILPKSSP SGITHVIASN ARIKAEKEKD
   181  NFKAPFYPIQ YLGDFLLEKE IQNDEDSQTN SVWTEHSNEE TNKDFRKDAG FLEMKGALRE
   241  TMYRTQKEMQ NHEDVNVGSI LIQHHKKEKF SGSSKDLKFV KMRNTFGSHT YENQKEIKKK
   301  DEDIQRSYTL RRKRKKGKES NCKKGVEHEK IKSTLRRHIY NRDQKEMKNS IFAEYAKESK
   361  AMAIKTDVDV VEIKNTLRKH IYRAQAVRYN CIRIDKQPVY NVEVKNAEFP RGVLNLIESL
   421  IEGHFFKEAI EELSTLQAHY IPPVCVLHAL LENVLQDNID TFSGRYFHIL SALLHLHPPW
   481  KSPAMSRYYL ELFQCPTCMK GAWSLVEVLI RSCLFNESFC HQISENIGSK VLHLTLLKFF
   541  FNLIESEVQH LSQKLYDWSD SQNLKITGKA MLLEIFWSGS ETSGLLTKPV NMLLEWTIYS
   601  HKEKFKSNDV FKHELAYLLA GILGAAIDYW IFLGLKMGRN VMRHMSDDLG SYVSLSCDDF
   661  SSQELEIFIC SFSSSWLQMF VAEAVFKKLC LQSSGSVSSE PLSLQKMVYS YLPALGKTGV
   721  LGSGKIQVSK KIGQRPCFDS QRTLLMLNGT KQKQVEGLPE LLDLNLAKCS SSLKKLKKKS
   781  EGELSCSKEN CPSVVKKMNF HKTNLKGETA LHRACINNQV EKLILLLSLP GIDINVKDNA
   841  GWTPLHEACN YGNTVCVQEI LQRCPEVDLL TQVDGVTPLH DALSNGHVEI GKLLLQHGGP
   901  VLLQQRNAKG ELPLDYVVSP QIKEELFAIT KIEDTVENFH AQAEKHFHYQ QLEFGSFLLS
   961  RMLLNFCSIF DLSSEFILAS KGLTHLNELL MACKSHKETT SVHTDWLLDL YAGNIKTLQK
  1021  LPHILKELPE NLKVCPGVHT EALMITLEMM CRSVMEFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 7.2 nTPM

Expression across tissuesHPA

Tissue

testis: 7.2 nTPM
cerebellum: 4.1 nTPM
skin: 3.3 nTPM
bone marrow: 3.2 nTPM
thymus: 3.2 nTPM
lymph node: 3.1 nTPM

Single-cell type

early primary spermatocytes: 223 nCPM
differentiating spermatogonia: 170 nCPM
neutrophils: 153 nCPM
sertoli cells: 147 nCPM
brain excitatory neurons: 124 nCPM
erythrocyte progenitors: 121 nCPM

Immune cell

neutrophil: 7.3 nTPM
naive B-cell: 3.6 nTPM
memory CD8 T-cell: 3.3 nTPM
memory CD4 T-cell: 2.6 nTPM
memory B-cell: 2.3 nTPM
gdT-cell: 1.7 nTPM

Brain region

cerebellum: 17 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 12 nTPM
white matter: 11 nTPM
amygdala: 9.4 nTPM
thalamus: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

BRCT domain
Ankyrin repeat
BRCT domain superfamily
Ankyrin repeat-containing domain superfamily
TopBP1/SLF1, BRCT domain
Ankyrin repeats (3 copies)
Regulator of Ty1 transposition protein 107 BRCT domain
TopBP1/SLF1, BRCT domain
SMC5-SMC6 complex localization factor protein 1
SMC5-SMC6 complex localization factor protein 1, BRCT domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLF1 as an antibody target. Whether an autoantibody or antibody against SLF1 could matter depends on whether native SLF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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