Seroatlas · Human Serome Atlas

SLCO6A1

Solute carrier organic anion transporter family member 6A1

Also known as: CT48, MGC26949, OATP6A1, OATPY, SO6A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UG4
Gene
SLCO6A1
Ensembl
ENSG00000205359
Chromosome
5
Canonical length
719 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be part of CatSper complex. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

719 residues, UniProt reviewed canonical sequence.

>Q86UG4|SLCO6A1
     1  MFVGVARHSG SQDEVSRGVE PLEAARAQPA KDRRAKGTPK SSKPGKKHRY LRLLPEALIR
    61  FGGFRKRKKA KSSVSKKPGE VDDSLEQPCG LGCLVSTCCE CCNNIRCFMI FYCILLICQG
   121  VVFGLIDVSI GDFQKEYQLK TIEKLALEKS YDISSGLVAI FIAFYGDRKK VIWFVASSFL
   181  IGLGSLLCAF PSINEENKQS KVGIEDICEE IKVVSGCQSS GISFQSKYLS FFILGQTVQG
   241  IAGMPLYILG ITFIDENVAT HSAGIYLGIA ECTSMIGYAL GYVLGAPLVK VPENTTSATN
   301  TTVNNGSPEW LWTWWINFLF AAVVAWCTLI PLSCFPNNMP GSTRIKARKR KQLHFFDSRL
   361  KDLKLGTNIK DLCAALWILM KNPVLICLAL SKATEYLVII GASEFLPIYL ENQFILTPTV
   421  ATTLAGLVLI PGGALGQLLG GVIVSTLEMS CKALMRFIMV TSVISLILLV FIIFVRCNPV
   481  QFAGINEDYD GTGKLGNLTA PCNEKCRCSS SIYSSICGRD DIEYFSPCFA GCTYSKAQNQ
   541  KKMYYNCSCI KEGLITADAE GDFIDARPGK CDAKCYKLPL FIAFIFSTLI FSGFSGVPIV
   601  LAMTRVVPDK LRSLALGVSY VILRIFGTIP GPSIFKMSGE TSCILRDVNK CGHTGRCWIY
   661  NKTKMAFLLV GICFLCKLCT IIFTTIAFFI YKRRLNENTD FPDVTVKNPK VKKKEETDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO6A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • testis: 28 nTPM
  • placenta: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late primary spermatocytes: 379 nCPM
  • early spermatids: 147 nCPM
  • early primary spermatocytes: 96 nCPM
  • late spermatids: 19 nCPM
  • undifferentiated spermatogonia: 13 nCPM
  • salivary duct cells: 6.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLCO6A1.

Disease | ImmuneIEDB

Conditions an epitope on SLCO6A1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
0.51
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO6A1 as an antibody target. Whether an autoantibody or antibody against SLCO6A1 could matter depends on whether native SLCO6A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO6A1 is annotated at the cell surface, where native SLCO6A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO6A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLCO6A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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