Seroatlas · Human Serome Atlas

SLCO5A1

Solute carrier organic anion transporter family member 5A1

Also known as: OATP-J, OATP5A1, OATPRP4, SLC21A15, SO5A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2Y9
Gene: SLCO5A1
Ensembl: ENSG00000137571
Chromosome: 8
Canonical length: 848 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

848 residues, UniProt reviewed canonical sequence.

>Q9H2Y9|SLCO5A1
     1  MDEGTGLQPG AGEQLEAPAT AEAVQERCEP ETLRSKSLPV LSSASCRPSL SPTSGDANPA
    61  FGCVDSSGHQ ELKQGPNPLA PSPSAPSTSA GLGDCNHRVD LSKTFSVSSA LAMLQERRCL
   121  YVVLTDSRCF LVCMCFLTFI QALMVSGYLS SVITTIERRY SLKSSESGLL VSCFDIGNLV
   181  VVVFVSYFGG RGRRPLWLAV GGLLIAFGAA LFALPHFISP PYQIQELNAS APNDGLCQGG
   241  NSTATLEPPA CPKDSGGNNH WVYVALFICA QILIGMGSTP IYTLGPTYLD DNVKKENSSL
   301  YLAIMYVMGA LGPAVGYLLG GLLIGFYVDP RNPVHLDQND PRFIGNWWSG FLLCAIAMFL
   361  VIFPMFTFPK KLPPRHKKKK KKKFSVDAVS DDDVLKEKSN NSEQADKKVS SMGFGKDVRD
   421  LPRAAVRILS NMTFLFVSLS YTAESAIVTA FITFIPKFIE SQFGIPASNA SIYTGVIIVP
   481  SAGVGIVLGG YIIKKLKLGA RESAKLAMIC SGVSLLCFST LFIVGCESIN LGGINIPYTT
   541  GPSLTMPHRN LTGSCNVNCG CKIHEYEPVC GSDGITYFNP CLAGCVNSGN LSTGIRNYTE
   601  CTCVQSRQVI TPPTVGQRSQ LRVVIVKTYL NENGYAVSGK CKRTCNTLIP FLVFLFIVTF
   661  ITACAQPSAI IVTLRSVEDE ERPFALGMQF VLLRTLAYIP TPIYFGAVID TTCMLWQQEC
   721  GVQGSCWEYN VTSFRFVYFG LAAGLKFVGF IFIFLAWYSI KYKEDGLQRR RQREFPLSTV
   781  SERVGHPDNA RTRSCPAFST QGEFHEETGL QKGIQCAAQT YPGPFPEAIS SSADPGLEES
   841  PAALEPPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO5A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

tongue: 10 nTPM
skeletal muscle: 7.1 nTPM
thymus: 6.1 nTPM
heart muscle: 3.4 nTPM
prostate: 2.1 nTPM
pituitary gland: 1.4 nTPM

Single-cell type

myonuclei: 604 nCPM
gonadotrophs: 295 nCPM
corticotrophs: 271 nCPM
prostatic glandular cells: 166 nCPM
cardiomyocytes: 134 nCPM
retinal amacrine cells: 109 nCPM

Immune cell

basophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 2.3 nTPM
cerebral cortex: 1.9 nTPM
basal ganglia: 1.8 nTPM
hippocampal formation: 1.5 nTPM
pons: 1.5 nTPM
medulla oblongata: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 0.9
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sodium-independent organic anion transport

Molecular functions

sodium-independent organic anion transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO5A1 as an antibody target. Whether an autoantibody or antibody against SLCO5A1 could matter depends on whether native SLCO5A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO5A1 is annotated at the cell surface, where native SLCO5A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO5A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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