Seroatlas · Human Serome Atlas

SLCO4A1

Solute carrier organic anion transporter family member 4A1

Also known as: OATP-E, OATP4A1, SLC21A12, SO4A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BD0
Gene: SLCO4A1
Ensembl: ENSG00000101187
Chromosome: 20
Canonical length: 722 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Cell Junctions

OverviewNCBI Gene

Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

722 residues, UniProt reviewed canonical sequence.

>Q96BD0|SLCO4A1
     1  MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC
    61  QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV
   121  NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM
   181  GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG
   241  ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT
   301  TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA
   361  SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE
   421  AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP
   481  MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET
   541  NVDGQKVYRD CSCIPQNLSS GFGHATAGKC TSTCQRKPLL LVFIFVVIFF TFLSSIPALT
   601  ATLRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG QQGSCLVYQN
   661  SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE TCLPSQSSAP DSATDSQLQS
   721  SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO4A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

lung: 56 nTPM
heart muscle: 47 nTPM
kidney: 39 nTPM
adipose tissue: 32 nTPM
midbrain: 26 nTPM
skin: 25 nTPM

Single-cell type

extravillous trophoblasts: 363 nCPM
esophageal apical cells: 158 nCPM
melanocytes: 103 nCPM
endometrial glandular cells: 87 nCPM
vascular endothelial cells: 83 nCPM
rod photoreceptor cells: 55 nCPM

Immune cell

T-reg: 1.6 nTPM
myeloid DC: 0.9 nTPM
memory B-cell: 0.8 nTPM
naive B-cell: 0.7 nTPM
naive CD4 T-cell: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

thalamus: 31 nTPM
pons: 23 nTPM
medulla oblongata: 20 nTPM
amygdala: 20 nTPM
cerebral cortex: 20 nTPM
spinal cord: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Kazal domain
Organic anion transporter polypeptide
Major facilitator superfamily domain
Kazal domain superfamily
MFS transporter superfamily
Organic Anion Transporter Polypeptide (OATP) family
Kazal-type serine protease inhibitor domain
Solute carrier organic anion transporter family member 4A1-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO4A1 as an antibody target. Whether an autoantibody or antibody against SLCO4A1 could matter depends on whether native SLCO4A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO4A1 is annotated at the cell surface, where native SLCO4A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO4A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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