Seroatlas · Human Serome Atlas

SLCO3A1

Solute carrier organic anion transporter family member 3A1

Also known as: OATP-D, OATP3A1, SLC21A11, SO3A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIG8
Gene
SLCO3A1
Ensembl
ENSG00000176463
Chromosome
15
Canonical length
710 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in positive regulation of MAPK cascade; positive regulation of canonical NF-kappaB signal transduction; and prostaglandin transport. Located in basal plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

710 residues, UniProt reviewed canonical sequence.

>Q9UIG8|SLCO3A1
     1  MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM LAQGTVGAYL
    61  VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG ARGHRPRLIG CGGIVMALGA
   121  LLSALPEFLT HQYKYEAGEI RWGAEGRDVC AANGSGGDEG PDPDLICRNR TATNMMYLLL
   181  IGAQVLLGIG ATPVQPLGVS YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY
   241  VDAVFIDTSN LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE
   301  QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV FTCIILAACM
   361  EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC LGIFLGGLLV KKLSLSALGA
   421  IRMAMLVNLV STACYVSFLF LGCDTGPVAG VTVPYGNSTA PGSALDPYSP CNNNCECQTD
   481  SFTPVCGADG ITYLSACFAG CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL
   541  CVMCICSLIG AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
   601  CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK NYKRYIKNHE
   661  GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH EWCENMESVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO3A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 39 nTPM
  • heart muscle: 25 nTPM
  • hippocampal formation: 22 nTPM
  • choroid plexus: 20 nTPM
  • midbrain: 20 nTPM
  • testis: 17 nTPM

Single-cell type

  • neutrophils: 2,015 nCPM
  • choroid plexus epithelial cells: 868 nCPM
  • oligodendrocytes: 800 nCPM
  • ocular epithelial cells: 694 nCPM
  • neutrophil progenitors: 521 nCPM
  • monocytes: 479 nCPM

Immune cell

  • neutrophil: 7.5 nTPM
  • eosinophil: 6.9 nTPM
  • basophil: 4.3 nTPM
  • T-reg: 2.7 nTPM
  • classical monocyte: 2.4 nTPM
  • intermediate monocyte: 2 nTPM

Brain region

  • white matter: 71 nTPM
  • cerebellum: 62 nTPM
  • medulla oblongata: 56 nTPM
  • midbrain: 53 nTPM
  • basal ganglia: 51 nTPM
  • pons: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.39
gnomAD missense Z
2.86
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO3A1 as an antibody target. Whether an autoantibody or antibody against SLCO3A1 could matter depends on whether native SLCO3A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO3A1 is annotated at the cell surface, where native SLCO3A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO3A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLCO3A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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