Seroatlas · Human Serome Atlas

SLCO2A1

Solute carrier organic anion transporter family member 2A1

Also known as: MATR1, OATP2A1, PGT, SLC21A2, SO2A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92959
Gene: SLCO2A1
Ensembl: ENSG00000174640
Chromosome: 3
Canonical length: 643 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>Q92959|SLCO2A1
     1  MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA YFKSSLTTIE
    61  KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL IGIGGLFLAA GAFILTLPHF
   121  LSEPYQYTLA STGNNSRLQA ELCQKHWQDL PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA
   181  GIGTVPIQPF GISYVDDFSE PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN
   241  TAAVNLVPGD PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE
   301  EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN KFLEKQYGTS
   361  AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI ATTIITISMI LCVPLFFMGC
   421  STPTVAEVYP PSTSSSIHPQ SPACRRDCSC PDSIFHPVCG DNGIEYLSPC HAGCSNINMS
   481  SATSKQLIYL NCSCVTGGSA SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV
   541  LRVVNQEEKS FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND
   601  ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

lung: 120 nTPM
thyroid gland: 88 nTPM
seminal vesicle: 80 nTPM
kidney: 52 nTPM
adrenal gland: 43 nTPM
endometrium: 42 nTPM

Single-cell type

vascular endothelial cells: 577 nCPM
lymphatic endothelial cells: 92 nCPM
colonocytes: 68 nCPM
salivary basal cells: 64 nCPM
foveolar cells: 64 nCPM
conjunctival goblet cells: 62 nCPM

Immune cell

plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 18 nTPM
thalamus: 4.2 nTPM
cerebral cortex: 4 nTPM
pons: 3.7 nTPM
medulla oblongata: 3.1 nTPM
spinal cord: 2.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLCO2A1.

Disease | AllUniProt

Conditions SLCO2A1 is implicated in, by any mechanism.

PHOAR2-enteropathy syndrome (PHOAR2E) MIM:614441
Hypertrophic osteoarthropathy, primary, autosomal dominant (PHOAD) MIM:167100

Disease | GeneticClinVar

64 pathogenic / likely-pathogenic of 390 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2
Hypertrophic osteoarthropathy, primary, autosomal dominant
Hepatocellular carcinoma
Cervical cancer
Pachydermoperiostosis syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO2A1 as an antibody target. Whether an autoantibody or antibody against SLCO2A1 could matter depends on whether native SLCO2A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO2A1 is annotated at the cell surface, where native SLCO2A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO2A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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