Seroatlas · Human Serome Atlas

SLCO1B7

Putative solute carrier organic anion transporter family member 1B7

Also known as: SO1B7_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: G3V0H7
Gene: SLCO1B7
Canonical length: 640 aa

OverviewNCBI Gene

No narrative summary is available for SLCO1B7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

640 residues, UniProt reviewed canonical sequence.

>G3V0H7|SLCO1B7
     1  MKISTTQIER RFEISSSLVG LIDGSFEIGN LFVIVFVSYF GSKLHRPKLI GIGCFLMGTG
    61  SILMALPHFF MGYYRYSKET NIDPSENSTS NLPNCLINQM LSLNRTPSEI IERGCVKESG
   121  SHMWIYVFMG NMLRGIGETP IVPLGISYID DFAKEGHSSL YLGTVNVMGM TGLVFAFMLG
   181  SLFAKMYVDI GYVDLSTIRI TPKDSRWVGA WWLGFLVSGI VSIISSIPFF FLPLNPNKPQ
   241  KERKVSLFLH VLKTNDKRNQ IANLTNRRKY ITKNVTGFFQ SLKSILTNPL YVIFVIFTLL
   301  HMSSYIASLT YIIKMVEQQY GWSASKTNFL LGVLALPAVA IGMFSGGYII KKFKLSLVGL
   361  AKLAFCSATV HLLSQVLYFF LICESKSVAG LTLTYDGNSP VRSHVDVPLS YCNSECNCDE
   421  SQWEPVCGNN GITYLSPCLA GCKSSSGNKE PIVFYNCSCV EVIGLQNKNY SAHLGECPRD
   481  DACTRKSYVY FVIQVLDAFL CAVGLTSYSV LVIRIVQPEL KALAIGFHSM IMRSLGGILV
   541  PIYFGALIDT TCMKWSTNSC GARGACRIYN STYLGRAFFG LKVALIFPVL VLLTVFIFVV
   601  RKKSHGKDTK VLENERQVMD EANLEFLNDS EHFVPSAEEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO1B7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.29

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -0.96

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

basolateral plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO1B7 as an antibody target. Whether an autoantibody or antibody against SLCO1B7 could matter depends on whether native SLCO1B7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO1B7 is annotated at the cell surface, where native SLCO1B7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO1B7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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