Seroatlas · Human Serome Atlas

SLCO1B3-SLCO1B7

SLCO1B3-SLCO1B7 readthrough transcript protein

Also known as: SO1BT_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: F5H094
Gene: SLCO1B3-SLCO1B7
Canonical length: 687 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for SLCO1B3-SLCO1B7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

687 residues, UniProt reviewed canonical sequence.

>F5H094|SLCO1B3-SLCO1B7
     1  MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI SITQIERRFD
    61  ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CLLMGTGSIL TSLPHFFMGY
   121  YRYSKETNID PSENSTSNLP NCLINQMLSL NRTPSEIIER GCVKESGSHM WIYVFMGNML
   181  RGIGETPIVP LGISYIDDFA KEGHSSLYLG TVNVMGMTGL VFAFMLGSLF AKMYVDIGYV
   241  DLSTIRITPK DSRWVGAWWL GFLVSGIVSI ISSIPFFFLP LNPNKPQKER KVSLFLHVLK
   301  TNDKRNQIAN LTNRRKYITK NVTGFFQSLK SILTNPLYVI FVIFTLLHMS SYIASLTYII
   361  KMVEQQYGWS ASKTNFLLGV LALPAVAIGM FSGGYIIKKF KLSLVGLAKL AFCSATVHLL
   421  SQVLYFFLIC ESKSVAGLTL TYDGNSPVRS HVDVPLSYCN SECNCDESQW EPVCGNNGIT
   481  YLSPCLAGCK SSSGNKEPIV FYNCSCVEVI GLQNKNYSAH LGECPRDDAC TRKSYVYFVI
   541  QVLDAFLCAV GLTSYSVLVI RIVQPELKAL AIGFHSMIMR SLGGILVPIY FGALIDTTCM
   601  KWSTNSCGAR GACRIYNSTY LGRAFFGLKV ALIFPVLVLL TVFIFVVRKK SHGKDTKVLE
   661  NERQVMDEAN LEFLNDSEHF VPSAEEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO1B3-SLCO1B7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

breast: 20 nTPM
liver: 3.8 nTPM
cervix: 0.5 nTPM
choroid plexus: 0.5 nTPM
testis: 0.3 nTPM
adipose tissue: 0 nTPM

Single-cell type

hepatocytes: 171 nCPM
choroid plexus epithelial cells: 28 nCPM
conjunctival goblet cells: 16 nCPM
cholangiocytes: 7.2 nCPM
undifferentiated spermatogonia: 7.1 nCPM
respiratory deuterosomal cells: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.6 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO1B3-SLCO1B7 as an antibody target. Whether an autoantibody or antibody against SLCO1B3-SLCO1B7 could matter depends on whether native SLCO1B3-SLCO1B7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO1B3-SLCO1B7 is annotated at the cell surface, where native SLCO1B3-SLCO1B7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO1B3-SLCO1B7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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