Seroatlas · Human Serome Atlas

SLCO1A2

Solute carrier organic anion transporter family member 1A2

Also known as: OATP, OATP-A, OATP1A2, SLC21A3, SO1A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46721
Gene
SLCO1A2
Ensembl
ENSG00000084453
Chromosome
12
Canonical length
670 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>P46721|SLCO1A2
     1  MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ FNIPTSLVGF
    61  INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC FLKSLPHFLM NQYEYESTVS
   121  VSGNLSSNSF LCMENGTQIL RPTQDPSECT KEVKSLMWVY VLVGNIVRGM GETPILPLGI
   181  SYIEDFAKFE NSPLYIGLVE TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR
   241  WVGAWWFGFL ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG
   301  ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS SSDAIFLMGI
   361  YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL LYFLSFLMTC ENSSVVGINT
   421  SYEGIPQDLY VENDIFADCN VDCNCPSKIW DPVCGNNGLS YLSACLAGCE TSIGTGINMV
   481  FQNCSCIQTS GNSSAVLGLC DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK
   541  SEEKSLGVGL HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI
   601  YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE CKDIYQKSTV
   661  LKDDELKTKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO1A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 15 nTPM
  • salivary gland: 15 nTPM
  • liver: 7.5 nTPM
  • choroid plexus: 7 nTPM
  • breast: 3.2 nTPM
  • lung: 2.5 nTPM

Single-cell type

  • oligodendrocytes: 530 nCPM
  • retinal pigment epithelial cells: 226 nCPM
  • bergmann glia: 42 nCPM
  • somatotrophs: 37 nCPM
  • vascular endothelial cells: 28 nCPM
  • loop of henle epithelial cells: 26 nCPM

Immune cell

  • neutrophil: 1.3 nTPM
  • MAIT T-cell: 0.6 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.6 nTPM
  • T-reg: 0.6 nTPM
  • naive CD8 T-cell: 0.5 nTPM

Brain region

  • white matter: 140 nTPM
  • basal ganglia: 105 nTPM
  • medulla oblongata: 81 nTPM
  • pons: 76 nTPM
  • midbrain: 75 nTPM
  • cerebral cortex: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO1A2 as an antibody target. Whether an autoantibody or antibody against SLCO1A2 could matter depends on whether native SLCO1A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO1A2 is annotated at the cell surface, where native SLCO1A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO1A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLCO1A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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