SLC51B

Protein identityUniProt · HPA

UniProt accession

Q86UW2

Gene

SLC51B

Ensembl

ENSG00000186198

Chromosome

15

Canonical length

128 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Vesicles,Mitochondria

OverviewNCBI Gene

Predicted to enable bile acid transmembrane transporter activity and protein heterodimerization activity. Involved in bile acid secretion. Located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q86UW2|SLC51B
     1  MEHSEGAPGD PAGTVVPQEL LEEMLWFFRV EDASPWNHSI LALAAVVVII SMVLLGRSIQ
    61  ASRKEKMQPP EKETPEVLHL DEAKDHNSLN NLRETLLSEK PNLAQVELEL KERDVLSVFL
   121  PDVPETES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC51B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

101 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC51B.

Disease | AllUniProt

Conditions SLC51B is implicated in, by any mechanism.

• Bile acid malabsorption, primary, 2 (PBAM2) MIM:619481

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cholestasis
• Diarrhea
• Bile acid malabsorption, primary, 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.36

gnomAD pLI

0.24

gnomAD missense Z

0.46

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• bile acid and bile salt transport
• bile acid secretion
• positive regulation of glycoprotein biosynthetic process
• positive regulation of protein exit from endoplasmic reticulum
• positive regulation of protein targeting to membrane
• regulation of protein stability

Molecular functions

• bile acid transmembrane transporter activity
• protein heterodimerization activity

Cellular components

• basolateral plasma membrane
• membrane
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Organic solute transporter subunit beta
• Organic solute transporter beta subunit
• Organic solute transporter subunit beta protein

KeywordsUniProt

• Cell membrane
• Lipid transport
• Membrane
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of SLC51B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SLC51A