Seroatlas · Human Serome Atlas

SLC51A

Organic solute transporter subunit alpha

Also known as: OSTA_HUMAN, OSTalpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UW1
Gene
SLC51A
Ensembl
ENSG00000163959
Chromosome
3
Canonical length
340 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable protein heterodimerization activity; protein homodimerization activity; and transmembrane transporter activity. Involved in bile acid secretion. Located in basolateral plasma membrane. Implicated in progressive familial intrahepatic cholestasis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q86UW1|SLC51A
     1  MEPGRTQIKL DPRYTADLLE VLKTNYGIPS ACFSQPPTAA QLLRALGPVE LALTSILTLL
    61  ALGSIAIFLE DAVYLYKNTL CPIKRRTLLW KSSAPTVVSV LCCFGLWIPR SLVLVEMTIT
   121  SFYAVCFYLL MLVMVEGFGG KEAVLRTLRD TPMMVHTGPC CCCCPCCPRL LLTRKKLQLL
   181  MLGPFQYAFL KITLTLVGLF LVPDGIYDPA DISEGSTALW INTFLGVSTL LALWTLGIIS
   241  RQARLHLGEQ NMGAKFALFQ VLLILTALQP SIFSVLANGG QIACSPPYSS KTRSQVMNCH
   301  LLILETFLMT VLTRMYYRRK DHKVGYETFS SPDLDLNLKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC51A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • liver: 67 nTPM
  • small intestine: 61 nTPM
  • duodenum: 29 nTPM
  • colon: 11 nTPM
  • bone marrow: 5.6 nTPM
  • kidney: 5.1 nTPM

Single-cell type

  • enterocytes: 312 nCPM
  • cardiomyocytes: 112 nCPM
  • peritubular myoid cells: 96 nCPM
  • epicardial cells: 89 nCPM
  • neutrophil progenitors: 67 nCPM
  • colonocytes: 66 nCPM

Immune cell

  • eosinophil: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • hypothalamus: 4.9 nTPM
  • cerebral cortex: 4.7 nTPM
  • white matter: 4.1 nTPM
  • medulla oblongata: 3.9 nTPM
  • pons: 3.8 nTPM
  • midbrain: 3.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC51A.

Disease | AllUniProt

Conditions SLC51A is implicated in, by any mechanism.

  • Cholestasis, progressive familial intrahepatic, 6 (PFIC6) MIM:619484

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cholestasis, progressive familial intrahepatic, 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.07
gnomAD missense Z
0.22
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC51A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC51A as an antibody target. Whether an autoantibody or antibody against SLC51A could matter depends on whether native SLC51A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC51A is annotated at the cell surface, where native SLC51A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC51A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC51A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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