Seroatlas · Human Serome Atlas

SLC49A4

Solute carrier family 49 member 4

Also known as: DIRC2, DIRC2_HUMAN, FLJ14784, RCC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96SL1
Gene
SLC49A4
Ensembl
ENSG00000138463
Chromosome
3
Canonical length
478 aa
Protein class
Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q96SL1|SLC49A4
     1  MGSRWSSEEE RQPLLGPGLG PGLGASWRSR EAAAAALPAA VPGPGRVYGR RWLVLLLFSL
    61  LAFVQGLVWN TWGPIQNSAR QAYGFSSWDI ALLVLWGPIG FLPCFAFMWL LDKRGLRITV
   121  LLTSFLMVLG TGLRCIPISD LILKRRLIHG GQMLNGLAGP TVMNAAPFLS TTWFSADERA
   181  TATAIASMLS YLGGACAFLV GPLVVPAPNG TSPLLAAESS RAHIKDRIEA VLYAEFGVVC
   241  LIFSATLAYF PPRPPLPPSV AAASQRLSYR RSVCRLLSNF RFLMIALAYA IPLGVFAGWS
   301  GVLDLILTPA HVSQVDAGWI GFWSIVGGCV VGIAMARFAD FIRGMLKLIL LLLFSGATLS
   361  STWFTLTCLN SITHLPLTTV TLYASCILLG VFLNSSVPIF FELFVETVYP VPEGITCGVV
   421  TFLSNMFMGV LLFFLTFYHT ELSWFNWCLP GSCLLSLLLI LCFRESYDRL YLDVVVSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC49A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 17 nTPM
  • tongue: 13 nTPM
  • parathyroid gland: 12 nTPM
  • pancreas: 7.2 nTPM
  • placenta: 7.1 nTPM
  • skin: 6.2 nTPM

Single-cell type

  • neutrophils: 1,106 nCPM
  • syncytiotrophoblasts: 589 nCPM
  • myonuclei: 327 nCPM
  • neutrophil progenitors: 258 nCPM
  • monocytes: 255 nCPM
  • macrophages: 177 nCPM

Immune cell

  • neutrophil: 0.9 nTPM
  • classical monocyte: 0.2 nTPM
  • gdT-cell: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • myeloid DC: 0.1 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • hypothalamus: 12 nTPM
  • white matter: 12 nTPM
  • thalamus: 12 nTPM
  • hippocampal formation: 12 nTPM
  • pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC49A4 as an antibody target. Whether an autoantibody or antibody against SLC49A4 could matter depends on whether native SLC49A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC49A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC49A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC49A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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