Seroatlas · Human Serome Atlas

SLC49A3

Solute carrier family 49 member A3

Also known as: FLJ22269, LP2561, MFSD7, S49A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXD7
Gene: SLC49A3
Ensembl: ENSG00000169026
Chromosome: 4
Canonical length: 560 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q6UXD7|SLC49A3
     1  MAGPTEAETG LAEPRALCAQ RGHRTYARRW VFLLAISLLN CSNATLWLSF APVADVIAED
    61  LVLSMEQINW LSLVYLVVST PFGVAAIWIL DSVGLRAATI LGAWLNFAGS VLRMVPCMVV
   121  GTQNPFAFLM GGQSLCALAQ SLVIFSPAKL AALWFPEHQR ATANMLATMS NPLGVLVANV
   181  LSPVLVKKGE DIPLMLGVYT IPAGVVCLLS TICLWESVPP TPPSAGAASS TSEKFLDGLK
   241  LQLMWNKAYV ILAVCLGGMI GISASFSALL EQILCASGHS SGFSGLCGAL FITFGILGAL
   301  ALGPYVDRTK HFTEATKIGL CLFSLACVPF ALVSQLQGQT LALAATCSLL GLFGFSVGPV
   361  AMELAVECSF PVGEGAATGM IFVLGQAEGI LIMLAMTALT VRRSEPSLST CQQGEDPLDW
   421  TVSLLLMAGL CTFFSCILAV FFHTPYRRLQ AESGEPPSTR NAVGGADSGP GVDRGGAGRA
   481  GVLGPSTATP ECTARGASLE DPRGPGSPHP ACHRATPRAQ GPAATDAPSR PGRLAGRVQA
   541  SRFIDPAGSH SSFSSPWVIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC49A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

retina: 12 nTPM
skin: 11 nTPM
kidney: 9.7 nTPM
breast: 9.4 nTPM
spleen: 9.3 nTPM
testis: 9.1 nTPM

Single-cell type

late spermatids: 56 nCPM
late primary spermatocytes: 53 nCPM
extravillous trophoblasts: 46 nCPM
breast lactating cells: 40 nCPM
early spermatids: 37 nCPM
esophageal apical cells: 32 nCPM

Immune cell

neutrophil: 1.3 nTPM
classical monocyte: 0.6 nTPM
intermediate monocyte: 0.4 nTPM
NK-cell: 0.4 nTPM
total PBMC: 0.3 nTPM
myeloid DC: 0.2 nTPM

Brain region

thalamus: 9.7 nTPM
choroid plexus: 9.2 nTPM
medulla oblongata: 8.6 nTPM
white matter: 8.1 nTPM
pons: 8 nTPM
spinal cord: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC49A3 as an antibody target. Whether an autoantibody or antibody against SLC49A3 could matter depends on whether native SLC49A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC49A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC49A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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