Seroatlas · Human Serome Atlas

SLC46A3

Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

Also known as: DKFZp686A1775, FLJ42613, S46A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z3Q1
Gene
SLC46A3
Ensembl
ENSG00000139508
Chromosome
13
Canonical length
461 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytoplasm. This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of cancer cells. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q7Z3Q1|SLC46A3
     1  MKILFVEPAI FLSAFAMTLT GPLTTQYVYR RIWEETGNYT FSSDSNISEC EKNKSSPIFA
    61  FQEEVQKKVS RFNLQMDISG LIPGLVSTFI LLSISDHYGR KFPMILSSVG ALATSVWLCL
   121  LCYFAFPFQL LIASTFIGAF CGNYTTFWGA CFAYIVDQCK EHKQKTIRIA IIDFLLGLVT
   181  GLTGLSSGYF IRELGFEWSF LIIAVSLAVN LIYILFFLGD PVKECSSQNV TMSCSEGFKN
   241  LFYRTYMLFK NASGKRRFLL CLLLFTVITY FFVVIGIAPI FILYELDSPL CWNEVFIGYG
   301  SALGSASFLT SFLGIWLFSY CMEDIHMAFI GIFTTMTGMA MTAFASTTLM MFLARVPFLF
   361  TIVPFSVLRS MLSKVVRSTE QGTLFACIAF LETLGGVTAV STFNGIYSAT VAWYPGFTFL
   421  LSAGLLLLPA ISLCVVKCTS WNEGSYELLI QEESSEDASD R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC46A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
90 nTPM

Expression across tissuesHPA

Tissue

  • liver: 90 nTPM
  • small intestine: 72 nTPM
  • duodenum: 44 nTPM
  • parathyroid gland: 23 nTPM
  • gallbladder: 22 nTPM
  • colon: 19 nTPM

Single-cell type

  • enterocytes: 148 nCPM
  • breast lactating cells: 89 nCPM
  • sertoli cells: 86 nCPM
  • kupffer cells: 81 nCPM
  • thyrotrophs: 79 nCPM
  • retinal bipolar cells: 71 nCPM

Immune cell

  • basophil: 33 nTPM
  • non-classical monocyte: 20 nTPM
  • intermediate monocyte: 13 nTPM
  • myeloid DC: 12 nTPM
  • naive CD4 T-cell: 11 nTPM
  • plasmacytoid DC: 11 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • cerebellum: 16 nTPM
  • spinal cord: 14 nTPM
  • thalamus: 14 nTPM
  • pons: 12 nTPM
  • midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC46A3 as an antibody target. Whether an autoantibody or antibody against SLC46A3 could matter depends on whether native SLC46A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC46A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of cancer cells.

Canonical record: https://seroatlas.com/gene/SLC46A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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